Department of Food Safety and Quality Management, Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11080, Zemun, Belgrade, Serbia.
Department of Food Safety and Quality Management, Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11080, Zemun, Belgrade, Serbia.
Food Chem Toxicol. 2021 May;151:112116. doi: 10.1016/j.fct.2021.112116. Epub 2021 Mar 13.
Classified as Group 1 carcinogens aflatoxins (AFs) are of major concern for food safety and public health. Within the AFs group, aflatoxin B1 (AFB1) occurs at the highest levels in different food products and is considered as the most potent representative. A total of 463 samples of products susceptible to contamination with AFB1 and commonly consumed in Serbia were collected and analyzed. Consumption surveys were performed using a food frequency questionnaire (FFQ) and 24-h recall-based method. Monte Carlo simulation of 100,000 iterations was performed to estimate the intake of AFB1 through each food category, while a simple distribution approach was performed to estimate overall exposure of tested population groups. Risk characterization was performed by calculation of the Margin of Exposure (MOE) and by calculation of the number of possible hepatocellular carcinoma (HCC) cases. The highest exposure was observed in children with the mean overall estimated daily intake (EDI) in the range of 0.79-1.10 and 1.20-1.66 ng kg bw day, followed by adolescents 0.56-0.81 and 0.94-1.32 ng kg bw day, adult females 0.52-0.72 and 0.56-0.76 ng kg bw day and adult males with the mean overall EDI in the range of 0.39-0.56 and 0.47-0.66 ng kg bw day depending on consumption survey method and for the lower (LB) and upper bound (UB) scenario. MOE values that resulted from the mean values of the overall EDI of AFB1 were low, indicating high concern for all population groups. Based on obtained mean values of the overall EDI higher estimates of possible HCC cases caused by exposure to AFB1 were in the range of 0.01-0.02 cases/year/10 individuals, depending on the population group.
黄曲霉毒素（AFs）被归类为 1 类致癌物质，对食品安全和公共健康构成重大威胁。在 AFs 组中，黄曲霉毒素 B1（AFB1）在不同食品中的含量最高，被认为是最具代表性的物质。共采集并分析了塞尔维亚易受 AFB1 污染且常消费的 463 个产品样本。使用食物频率问卷（FFQ）和 24 小时回顾法进行消费调查。通过 100,000 次迭代的蒙特卡罗模拟来估计通过每种食物类别摄入的 AFB1，而简单的分布方法则用于估计测试人群的总体暴露情况。通过计算暴露量与安全限量的比值（MOE）和计算可能发生的肝细胞癌（HCC）病例数来进行风险特征描述。在儿童中观察到的暴露最高，其总体估计日摄入量（EDI）的平均值在 0.79-1.10 和 1.20-1.66 ng kg bw day 范围内，其次是青少年 0.56-0.81 和 0.94-1.32 ng kg bw day，成年女性 0.52-0.72 和 0.56-0.76 ng kg bw day，成年男性的总体 EDI 平均值在 0.39-0.56 和 0.47-0.66 ng kg bw day 范围内，具体取决于消费调查方法和低（LB）和高（UB）边界情景。基于 AFB1 总体 EDI 的平均值得出的 MOE 值较低，表明所有人群都高度关注。基于获得的总体 EDI 的平均值，由接触 AFB1 引起的可能 HCC 病例的更高估计值在每年每 10 人 0.01-0.02 例范围内，具体取决于人群。
