Salus Research, Inc., Fort Wayne, IN, USA.
Johnson & Johnson Consumer Inc., Skillman, NJ, USA
J Dent Hyg. 2022 Jun;96(3):21-34.
Various mechanical and chemotherapeutic methods are used to control dental plaque accumulation and prevent or reduce gingivitis. The purpose of this 12-week clinical trial was to investigate the effects of various combinations of supervised mechanical and chemotherapeutic regimens on the prevention and reduction of plaque, gingivitis, and gingival bleeding.Volunteers presenting with some evidence of gingivitis and no severe periodontitis were randomized into four groups: brush only (BO); brush/rinse (BR); brush/floss (BF); brush/floss/rinse (BFR) for this examiner-blinded clinical trial. Toothbrush, toothpaste, floss and a mouthrinse containing a fixed combination of four essential oils (EO) and training/instructions were provided to participants as per their assigned group. Participants performed their regimen at home, under virtual supervision, once each weekday; the second daily and weekend uses were unsupervised. Assessments included oral hard and soft tissue, plaque, gingivitis, and gingival bleeding (weeks 4, 12); probing depth and bleeding on probing (week 12).Of 213 enrolled participants, 209 completed the study. After 12 weeks, plaque, gingivitis, and gingival bleeding were significantly reduced in groups BR (35.8%, 50.8%, and 71.0% respectively, <0.001) and BFR (32.8%, 54.1%, and 78.2% respectively, <0.001) compared to BO. After 12 weeks, gingivitis and gingival bleeding were significantly reduced in the BF group (9.2%, =0.013 and 17.5%, =0.003, respectively), however there were no significant reductions in plaque in the BF group as compared to the BO group (=0.935).Oral care regimens that included a mouthrinse containing a fixed combination of four EOs (BR and BFR), demonstrated statistically significantly reduced plaque, gingivitis, and gingival bleeding as compared to BO and BF after 12 weeks. The BF regimen statistically significantly reduced gingivitis and gingival bleeding but did not statistically significantly reduce plaque compared to BO after 12 weeks.
各种机械和化学疗法方法用于控制牙菌斑的积累并预防或减少牙龈炎。本 12 周临床试验的目的是研究各种监督机械和化学疗法方案的组合对预防和减少菌斑、牙龈炎和牙龈出血的影响。患有一定程度牙龈炎且无严重牙周炎的志愿者被随机分为四组：仅刷牙（BO）；刷牙/漱口（BR）；刷牙/牙线（BF）；刷牙/牙线/漱口（BFR）进行这项 examiner-blinded 临床试验。根据他们分配的组别，为参与者提供牙刷、牙膏、牙线和含有四种精油（EO）的漱口水，并进行培训/指导。参与者在家中根据方案进行治疗，每周工作日接受虚拟监督一次；第二日的使用和周末的使用则无人监督。评估包括口腔硬组织和软组织、菌斑、牙龈炎和牙龈出血（第 4、12 周）；探诊深度和探诊出血（第 12 周）。在 213 名入组的参与者中，有 209 名完成了研究。12 周后，BR 组（分别为 35.8%、50.8%和 71.0%，<0.001）和 BFR 组（分别为 32.8%、54.1%和 78.2%，<0.001）的菌斑、牙龈炎和牙龈出血均显著减少。与 BO 组相比，BF 组（分别为 9.2%，=0.013 和 17.5%，=0.003）的牙龈炎和牙龈出血也显著减少，但与 BO 组相比，BF 组的菌斑无显著减少（=0.935）。含有四种精油（BR 和 BFR）的固定组合的漱口水的口腔护理方案，与 BO 和 BF 相比，在 12 周后显示出统计学上显著减少的菌斑、牙龈炎和牙龈出血。BF 方案在 12 周后在统计学上显著减少了牙龈炎和牙龈出血，但与 BO 相比，菌斑没有统计学上的显著减少。
