紫葡萄汁可提高业余跑步者的运动表现，但效果因基因型而异：一项双盲、随机、对照试验。
Purple grape juice improves performance of recreational runners, but the effect is genotype dependent: a double blind, randomized, controlled trial.
作者信息
de Sousa Bruno Rafael Virginio, de Lima Tavares Toscano Lydiane, de Almeida Filho Eder Jackson Bezerra, Sena Klécia Farias, Costa Matheus Silveira, de Souza Cunha Rebeka Correia, de Souza Siqueira Quintans Jullyana, Heimfarth Luana, Marques Aline Telles Biasoto, da Silva Darcilene Fiuza, de Campos Luis Felipe Castelli Correia, Persuhn Darlene Camati, Silva Alexandre Sérgio
机构信息
Programa de Pós-graduação em Ciências da Nutrição and Laboratório de Estudos do Treinamento Físico Aplicado ao Desempenho e a Saúde, Departamento de Educação Física, Universidade Federal da Paraíba (UFPB), João Pessoa, Paraíba, Brasil.
Laboratório de Estudos do Treinamento Físico Aplicado ao Desempenho e a Saúde, Departamento de Educação Física, Universidade Federal da Paraíba (UFPB), João Pessoa, Paraíba, Brasil, 58059-900.
出版信息
Genes Nutr. 2022 Jun 2;17(1):9. doi: 10.1186/s12263-022-00710-1.
BACKGROUND
We examined the influence of superoxide dismutase 3 (SOD3) Arg213Gly and Peroxisome Proliferator-Activated α-Receptor (PPARα) 7G/C polymorphisms to a single dose of purple grape juice supplementation on time-to-exhaustion running test, redox balance and muscle damage in recreational runners.
METHODS
Forty-seven male recreational runners performed a running test until exhaustion after supplementation with grape juice or a control drink. Serum total antioxidant capacity (TAC), malondialdehyde (MDA), plasma nitrite (NO), creatine kinase (CK) and lactate dehydrogenase (LDH) were measured pre and post exercise. Also, polymorphisms were analyzed in DNA extracted from the oral mucosa.
RESULTS
Grape juice improved the time-to-exhaustion. When analyzed by genotype, the recreational runners with GG+CG genotypes of the SOD3 gene had greater time-to-exhaustion than the CC genotype, but was no different for the PAPRα gene. A slight difference was noted in TAC, since the CC genotype of the SOD3 gene showed higher TAC values in the post-exercise compared to the baseline and with pre-exercise, but these values did not increase compared to the CG+GG group, respectively. The SOD3 and PPARα genes were similar at all times for the other biochemical variables.
CONCLUSION
The ergogenic effect of grape juice was genotype-dependent for SOD3 Arg213Gly. However, biochemical redox balance markers did not explain this difference.
背景
我们研究了超氧化物歧化酶3（SOD3）基因Arg213Gly多态性和过氧化物酶体增殖物激活受体α（PPARα）基因7G/C多态性对休闲跑步者单次补充紫葡萄汁后力竭时间、氧化还原平衡及肌肉损伤的影响。
方法
47名男性休闲跑步者在补充葡萄汁或对照饮料后进行力竭跑步测试。在运动前后测量血清总抗氧化能力（TAC）、丙二醛（MDA）、血浆亚硝酸盐（NO）、肌酸激酶（CK）和乳酸脱氢酶（LDH）。此外，对从口腔黏膜提取的DNA进行多态性分析。
结果
葡萄汁可延长力竭时间。按基因型分析，SOD3基因GG+CG基因型的休闲跑步者比CC基因型有更长的力竭时间，但PPARα基因无此差异。TAC有轻微差异，因为SOD3基因的CC基因型在运动后与基线及运动前相比显示出更高的TAC值，但与CG+GG组相比，这些值并未分别增加。其他生化变量在所有时间点上SOD3和PPARα基因情况相似。
结论
葡萄汁的促力竭效应在SOD3 Arg213Gly方面具有基因型依赖性。然而，生化氧化还原平衡标志物无法解释这种差异。
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