Nagahara K, Kishimoto S
Am J Otol. 1987 Jan;8(1):30-4.
Using a servocontrolled micropipet pressure measuring system, the effect of intravenous and oral administration of isosorbide, a hyperosmolar agent that is an anhydrate of sorbitol, was examined in 11 fasting cats. Following intravenous administration of 2 g/kg of the agent, perilymphatic pressure has shown, on the average, a significant reduction of 136% of the initial value (3.6 +/- 0.3 mm Hg). A strong rebound phenomenon, however, with a 61% rise to the initial value, was noted, and this did not come down in 3 hours. On the contrary, no rebound phenomenon was noted after oral administration, which caused a significant 60% drop in perilymphatic pressure for more than 90 minutes. Using polarographic technique, perilymphatic oxygen tension was measured and showed a maximal increase of 145% to the initial value. The time it took to reach the maximal PO2 tension was equal to the time it took to come down to the minimal perilymphatic pressure. This is a strong indication that isosorbide improves perfusion and increases blood flow of the inner ear vessels.
使用伺服控制的微量移液器压力测量系统，在11只禁食的猫身上研究了静脉注射和口服异山梨醇（一种山梨醇的无水物高渗剂）的效果。静脉注射2 g/kg该药物后，外淋巴压力平均显著降低至初始值的136%（3.6 +/- 0.3毫米汞柱）。然而，观察到强烈的反弹现象，上升至初始值的61%，且在3小时内未下降。相反，口服给药后未观察到反弹现象，外淋巴压力在90多分钟内显著下降60%。使用极谱技术测量外淋巴氧张力，显示最大增加至初始值的145%。达到最大PO2张力所需的时间与降至最低外淋巴压力所需的时间相等。这有力地表明异山梨醇可改善内耳血管的灌注并增加血流量。
