孕妇吸烟与口腔腭裂：一项基于人群的研究。
Maternal cigarette smoking and oral clefts: a population-based study.
作者信息
Khoury M J, Weinstein A, Panny S, Holtzman N A, Lindsay P K, Farrel K, Eisenberg M
出版信息
Am J Public Health. 1987 May;77(5):623-5. doi: 10.2105/ajph.77.5.623.
Abstract
Analyses of 1984 data from the Maryland Birth Defects Reporting and Information System indicate that mothers of infants with oral clefts (cleft lip with or without cleft palate; and cleft palate) smoked more during pregnancy than mothers of infants with other defects (odds ratio OR of 2.56 and 2.39, respectively). There was a dose-response relation between the daily amount smoked and the risk of clefting. Adjustment for available confounding variables did not account for the association between smoking and oral clefts.
摘要
对来自马里兰州出生缺陷报告与信息系统的1984年数据进行的分析表明，患有口腔腭裂（唇裂伴或不伴腭裂；以及腭裂）婴儿的母亲在孕期吸烟比患有其他缺陷婴儿的母亲更多（比值比分别为2.56和2.39）。每日吸烟量与腭裂风险之间存在剂量反应关系。对可用混杂变量进行调整并不能解释吸烟与口腔腭裂之间的关联。
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