Department of Pathology and Laboratory Medicine, McGovern Medical School, 12340The University of Texas Health Science Center at Houston, Houston, TX, USA.
Int J Surg Pathol. 2022 Dec;30(8):912-920. doi: 10.1177/10668969221088878. Epub 2022 Jun 3.
Invasive lobular carcinoma with papillary features is a newly proposed variant which presents as a relatively well-circumscribed mass lesion with at least partial peripheral thickened fibrous capsule and central delicate fibrovascular cores, morphologically mimicking encapsulated papillary carcinoma or solid papillary carcinoma. There are only 5 cases described in literature. We here report an interesting example of invasive lobular carcinoma with papillary growth pattern surrounded by a thick fibrous capsule, mimicking encapsulated papillary carcinoma (EPC). The lobular nature of the tumor was confirmed by the absence of membranous expression of E-cadherin and p120 catenin. The lobular cytological features are subtle in this variant and may be overlooked. Differentiation of this variant from papillary carcinomas is crucial for correct tumor categorization, staging and most importantly, proper treatment.
具有乳头状特征的浸润性小叶癌是一种新提出的变异型，表现为相对界限清楚的肿块病变，至少部分外周有增厚的纤维囊，中央有纤细的纤维血管核心，形态上类似于包膜型乳头状癌或实性乳头状癌。文献中仅描述了 5 例。我们在此报告一个有趣的浸润性小叶癌伴乳头状生长模式的病例，周围有厚纤维囊，类似于包膜型乳头状癌（EPC）。肿瘤的小叶性质通过 E-钙黏蛋白和 p120 连环蛋白的膜表达缺失得到确认。在这种变异型中，小叶细胞学特征较为细微，可能会被忽视。将这种变异型与乳头状癌区分开来对于正确的肿瘤分类、分期以及最重要的是正确的治疗至关重要。
