Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Breast J. 2020 Jun;26(6):1231-1233. doi: 10.1111/tbj.13784. Epub 2020 Feb 18.
Recently, a new variant of ILC with papillary architecture has been described, which may mimic solid and encapsulated papillary carcinomas of the breast. We report the fifth case of ILC with a solid papillary-like growth pattern, which was initially misdiagnosed as an encapsulated papillary carcinoma. Subtle discohesion in the tumor cells, coupled with the presence of classic invasive lobular carcinoma infiltrating beyond the capsule of the papillary tumor, prompted evaluation with E-cadherin, confirming the diagnosis. We review the histologic differential diagnosis and stress the importance of correct classification to ensure appropriate management for patients.
最近，描述了一种具有乳头状结构的 ILC 新变体，它可能模拟乳腺的实性和包裹性乳头状癌。我们报告了第五例具有实性乳头状样生长模式的 ILC，最初被误诊为包裹性乳头状癌。肿瘤细胞的轻微分离，加上经典的浸润性小叶癌超出乳头状肿瘤包膜的浸润，促使使用 E-钙黏蛋白进行评估，从而确诊。我们回顾了组织学鉴别诊断，并强调了正确分类的重要性，以确保为患者提供适当的治疗。
