From Clinical Cardiac Electrophysiology Federal University of São Paulo São Paulo Brazil.
Fundação Bahiana de Cardiologia Salvador Brazil.
J Am Heart Assoc. 2022 Jun 7;11(11):e022648. doi: 10.1161/JAHA.121.022648. Epub 2022 Jun 3.
Background Catheter ablation (CA) is a safe, effective, cost-effective technique and may be considered a first-line strategy for the treatment of symptomatic supraventricular tachycardias (SVT). Despite the high prospect of cure and the recommendations of international guidelines in considering CA as a first-line treatment strategy, the average time between diagnosis and the procedure may be long. The present study aims to evaluate predictors related to non-referral for CA as first-line treatment in patients with SVT. Methods and Results The model was derived from a retrospective cohort of patients with SVT or ventricular pre-excitation referred for CA in a tertiary center. Clinical and demographical features were used as independent variables and non-referral for CA as first-line treatment the dependent variable in a stepwise logistic regression analysis. Among 20 clinical-demographic variables from 350 patients, 10 were included in initial logistic regression analysis: age, women, presence of pre-excitation on ECG, palpitation, dyspnea and chest discomfort, number of antiarrhythmic drugs before ablation, number of concomitant symptoms, symptoms' duration and evaluations in the emergency room due to SVT. After multivariable adjusted analysis, age (odds ratio [OR], 1.2; 95% CI 1.01-1.32; =0.04), chest discomfort during supraventricular tachycardia (OR, 2.7; CI 1.6-4.7; <0.001) and number of antiarrhythmic drugs before ablation (OR, 1.8; CI 1.4-2.3; <0.001) showed a positive independent association for non-referral for CA as SVT first-line treatment. Conclusions The independent predictors of non-referral for CA as first-line treatment in our logistic regression analysis indicate the existence of biases in the decision-making process in the referral process of patients who would benefit the most from catheter ablation. They very likely suggest a skewed medical decision-making process leading to catheter ablation underuse.
导管消融(CA)是一种安全、有效且具有成本效益的技术,可被视为治疗有症状的室上性心动过速(SVT)的一线策略。尽管根治率高,且国际指南建议将 CA 作为一线治疗策略,但从诊断到实施 CA 的平均时间可能较长。本研究旨在评估与 SVT 患者 CA 一线治疗非转诊相关的预测因素。
该模型源自一家三级中心接受 CA 治疗的 SVT 或心室预激患者的回顾性队列。将临床和人口统计学特征作为自变量,将 CA 一线治疗的非转诊作为因变量,进行逐步逻辑回归分析。在 350 例患者的 20 项临床-人口统计学变量中,有 10 项纳入初始逻辑回归分析:年龄、女性、心电图存在预激、心悸、呼吸困难和胸痛、消融前抗心律失常药物的数量、同时存在的症状数量、症状持续时间以及因 SVT 而在急诊室进行的评估。多变量调整分析后,年龄(比值比[OR],1.2;95%置信区间[CI],1.01-1.32;=0.04)、SVT 期间胸痛(OR,2.7;CI,1.6-4.7;<0.001)和消融前抗心律失常药物数量(OR,1.8;CI,1.4-2.3;<0.001)与 CA 一线治疗非转诊呈正独立关联。
在我们的逻辑回归分析中,CA 一线治疗非转诊的独立预测因素表明,在最受益于导管消融的患者转诊过程中存在决策偏见。它们很可能表明存在偏向性的医疗决策过程,导致导管消融使用率不足。