Department of Cardiology, Ministry of Health, Kayseri City Hospital, Kayseri, Turkey.
Department of Cardiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Braz J Cardiovasc Surg. 2023 Feb 10;38(1):96-103. doi: 10.21470/1678-9741-2021-0278.
We investigated the relationship between the newly-defined systemic immune-inflammation index and the new-onset atrial fibrillation in patients undergoing coronary artery bypass grafting.
This study included 392 patients who underwent coronary artery bypass grafting. We divided the participants into two groups as those with and without new-onset atrial fibrillation. Prior to coronary artery bypass grafting, we evaluated blood samples, including systemic immune-inflammation index, and other laboratory parameters of the patients. We formulized the systemic immune-inflammation index score as platelet × neutrophil/lymphocyte counts.
The findings revealed that new-onset atrial fibrillation occurred in 80 (20.4%) of 392 patients during follow-ups. Such patients had higher systemic immune-inflammation index, neutrophil/lymphocyte ratio, and C-reactive protein levels than those who did not develop new-onset atrial fibrillation (P<0.001, P<0.001, P=0.010, respectively). In receiver operating characteristic curve analysis, systemic immune-inflammation index levels > 712.8 predicted new-onset atrial fibrillation with a sensitivity of 85% and a specificity of 61.2% (area under the curve: 0.781, 95% confidence interval: 0.727-0.835; P<0.001).
Overall, systemic immune-inflammation index, a novel inflammatory marker, may be used as a decisive marker to predict the development of atrial fibrillation following coronary artery bypass grafting.
我们研究了新定义的全身免疫炎症指数与接受冠状动脉旁路移植术患者新发心房颤动之间的关系。
这项研究纳入了 392 名接受冠状动脉旁路移植术的患者。我们将参与者分为新发心房颤动组和无新发心房颤动组。在冠状动脉旁路移植术前，我们评估了患者的血液样本，包括全身免疫炎症指数和其他实验室参数。我们将全身免疫炎症指数评分定义为血小板×中性粒细胞/淋巴细胞计数。
研究结果显示，392 名患者中有 80 名（20.4%）在随访期间发生新发心房颤动。新发心房颤动患者的全身免疫炎症指数、中性粒细胞/淋巴细胞比值和 C 反应蛋白水平均高于未发生新发心房颤动的患者（P<0.001、P<0.001、P=0.010）。在受试者工作特征曲线分析中，全身免疫炎症指数水平>712.8 预测新发心房颤动的敏感性为 85%，特异性为 61.2%（曲线下面积：0.781，95%置信区间：0.727-0.835；P<0.001）。
总体而言，全身免疫炎症指数作为一种新的炎症标志物，可用于预测冠状动脉旁路移植术后心房颤动的发生。
