Engineering Research Center of Fujian and Taiwan Special Marine Food Processing and Nutrition, Ministry of Education, Fuzhou, 350002, China.
College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
Plant Foods Hum Nutr. 2022 Jun;77(2):292-298. doi: 10.1007/s11130-022-00968-1. Epub 2022 Jun 3.
The aim of the present study was to investigate the anti-diabetic effect of CGSGCG and its beneficial effects on gut microbiota in type 2 diabetes (T2D) mice induced by streptozotocin and high sucrose and high fat diet. The results showed that treatment with CGSGCG reduced fasting blood glucose, improved oral glucose tolerance test, protected the liver from injury, and reduced inflammation in T2D mice. The contents of acetic acid, propionic acid, butyric acid, isobutyric acid, valeric acid and isovaleric acid in CGSGCG group were 2.49-, 1.74-, 3.31-, 1.93-, 1.36- and 1.30-fold than that of the model group. Moreover, administration of CGSGCG up-regulated the expression of INSR/IRS-1/PI3K/AKT/GLUT4 and mTOR but down-regulated the P38MAPK expression. Furthermore, the abundance of beneficial bacteria such as Verrucomicrobia, Proteobacteria, Osillibacter, Dubosiella and Lactococcus in intestinal tract increased, indicating that CGSCGG regulated and improved the bacterial community structure of T2D mice, which were closely related to glycometabolism.
本研究旨在探讨 CGSGCG 的抗糖尿病作用及其对链脲佐菌素和高蔗糖高脂肪饮食诱导的 2 型糖尿病（T2D）小鼠肠道微生物群的有益影响。结果表明，CGSGCG 治疗可降低空腹血糖，改善口服葡萄糖耐量试验，保护肝脏免受损伤，并减轻 T2D 小鼠的炎症。CGSGCG 组中乙酸、丙酸、丁酸、异丁酸、戊酸和异戊酸的含量分别比模型组高 2.49 倍、1.74 倍、3.31 倍、1.93 倍、1.36 倍和 1.30 倍。此外，CGSGCG 给药上调了 INSR/IRS-1/PI3K/AKT/GLUT4 和 mTOR 的表达，但下调了 P38MAPK 的表达。此外，肠道中有益菌（如厚壁菌门、变形菌门、 Oscillibacter、Dubosiella 和乳球菌）的丰度增加，表明 CGSCGG 调节和改善了 T2D 小鼠的细菌群落结构，这与糖代谢密切相关。
