Department of Population Medicine, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, ON, N1G 2W1, Canada.
Division of Microbiology, Alberta Precision Laboratories, Calgary, AB, Canada.
Infection. 2022 Dec;50(6):1579-1585. doi: 10.1007/s15010-022-01856-1. Epub 2022 Jun 3.
Extraintestinal pathogenic E. coli (ExPEC) are important pathogens causing community-acquired infections in humans, including bloodstream infections (BSIs), and may also colonize and infect animals. Our aim was to investigate associations between incidence rates (IRs) of BSIs caused by ExPEC and number of dogs and cats in communities in Calgary.
We used a well-characterized collection of blood isolates (n = 685) from Calgary, Alberta, Canada (2016). We used a combination of a seven-single-nucleotide-polymorphism quantitative PCR to type ExPEC into sequence types (STs). Calgary census data were used to estimate IRs per city community, as well as to investigate associations between number of companion animals per community, as obtained from licensing data, and IR of BSIs caused by each dominant ST.
From the 685 isolates available, ExPEC ST131 was most prevalent (21.3% of included isolates), followed by ST73 (13.7%), ST69 (8.2%), ST95 (6.7%), and ST1193 (5.3%), respectively. Incidence of BSIs caused by ExPECs among Calgary residents was 48.8 cases per 100,000 resident-years, whereas communities had on average of 1.7 companion animals per 10 residents. No association between the number of dogs and IR of BSIs caused by ExPECs was detected for any ST. Conversely, the incidence rate of BSIs caused by ST73 was 3.6 times higher (95%CI 1.3-9.99) for every increase of 1 cat per 10 habitants in communities.
Number of cats per habitant was positively associated with the incidence of BSIs caused by ExPEC ST73.
肠外致病性大肠杆菌（ExPEC）是引起人类社区获得性感染的重要病原体，包括血流感染（BSI），也可能定植和感染动物。我们的目的是调查由 ExPEC 引起的 BSI 发病率（IR）与卡尔加里社区中狗和猫数量之间的关联。
我们使用了来自加拿大阿尔伯塔省卡尔加里市（2016 年）的一组经过良好特征描述的血液分离株（n=685）。我们使用了一种七种单核苷酸多态性定量 PCR 组合来将 ExPEC 分为序列类型（ST）。我们使用卡尔加里人口普查数据来估计每个城市社区的 IR，并调查从许可数据中获得的每个社区伴侣动物数量与由每个主要 ST 引起的 BSI 的 IR 之间的关联。
在可用的 685 株分离株中，ExPEC ST131 最为普遍（占包含分离株的 21.3%），其次是 ST73（13.7%）、ST69（8.2%）、ST95（6.7%）和 ST1193（5.3%）。卡尔加里居民由 ExPEC 引起的 BSI 发病率为每 100,000 居民年 48.8 例，而社区平均每 10 名居民有 1.7 只伴侣动物。对于任何 ST，都没有检测到狗的数量与 ExPEC 引起的 BSI 的 IR 之间存在关联。相反，对于社区中每增加 1 只猫，ST73 引起的 BSI 的发病率增加 3.6 倍（95%CI 1.3-9.99）。
每 10 名居民中的猫的数量与 ExPEC ST73 引起的 BSI 的发生率呈正相关。
