Center for Molecular Design and Biomimetics at the Biodesign Institute, Arizona State University, Tempe, AZ, 85287, USA.
School of Molecular Sciences, Arizona State University, Tempe, AZ, 85287, USA.
J Nanobiotechnology. 2022 Jun 3;20(1):257. doi: 10.1186/s12951-022-01449-y.
Self-assembled photonic systems with well-organized spatial arrangement and engineered optical properties can be used as efficient energy materials and as effective biomedical agents. The lessons learned from natural light-harvesting antennas have inspired the design and synthesis of a series of biomimetic photonic complexes, including those containing strongly coupled dye aggregates with dense molecular packing and unique spectroscopic features. These photoactive components provide excellent features that could be coupled to multiple applications including light-harvesting, energy transfer, biosensing, bioimaging, and cancer therapy. Meanwhile, nanoscale DNA assemblies have been employed as programmable and addressable templates to guide the formation of DNA-directed multi-pigment complexes, which can be used to enhance the complexity and precision of artificial photonic systems and show the potential for energy and biomedical applications. This review focuses on the interface of DNA nanotechnology and biomimetic photonic systems. We summarized the recent progress in the design, synthesis, and applications of bioinspired photonic systems, highlighted the advantages of the utilization of DNA nanostructures, and discussed the challenges and opportunities they provide.
自组装光子系统具有组织良好的空间排列和工程光学特性，可用作高效能源材料和有效的生物医学试剂。从天然光捕获天线中获得的经验教训启发了一系列仿生光子配合物的设计和合成，包括含有强耦合染料聚集体的配合物，这些聚集体具有密集的分子堆积和独特的光谱特征。这些光活性组件提供了出色的特性，可以与多个应用程序相结合，包括光捕获、能量转移、生物传感、生物成像和癌症治疗。同时，纳米级 DNA 组装体被用作可编程和可寻址的模板，以指导 DNA 定向多色素配合物的形成，这可以用来提高人工光子系统的复杂性和精度，并显示出在能源和生物医学应用方面的潜力。本综述重点介绍 DNA 纳米技术和仿生光子系统的界面。我们总结了生物启发光子系统的设计、合成和应用的最新进展，强调了利用 DNA 纳米结构的优势，并讨论了它们提供的挑战和机遇。
