Hackett P H, Roach R C, Harrison G L, Schoene R B, Mills W J
Am Rev Respir Dis. 1987 Apr;135(4):896-8. doi: 10.1164/arrd.1987.135.4.896.
We studied the effects of almitrine, acetazolamide, and placebo on the hypoxic ventilatory response (HVR), sleep periodic breathing, and arterial oxygen saturation (SaO2) in 4 healthy climbers. In a laboratory on Denali (Mt. McKinley) at 4,400 m (PB = 440 mm Hg), we used a double-blind, randomized, three-way crossover design. The HVR was measured during the waking state. Periodic breathing and SAO2% were measured during 3-h sleep studies. Almitrine and acetazolamide both increased SaO2% during sleep, although almitrine increased periodic breathing, whereas acetazolamide decreased periodic breathing. The HVR (delta VE/delta SaO2%) was doubled with almitrine (p less than 0.05), but unchanged with acetazolamide. The HVR was positively related to periodic breathing (p less than 0.05). We conclude that periodic breathing during sleep at high altitude is related to the hypoxic ventilatory response, and that acetazolamide is a superior agent to almitrine for ameliorating periodic breathing.
我们研究了烯丙哌三嗪、乙酰唑胺和安慰剂对4名健康登山者的低氧通气反应（HVR）、睡眠周期性呼吸和动脉血氧饱和度（SaO2）的影响。在德纳里峰（麦金利山）海拔4400米（气压 = 440毫米汞柱）的实验室里，我们采用了双盲、随机、三因素交叉设计。在清醒状态下测量HVR。在3小时的睡眠研究中测量周期性呼吸和动脉血氧饱和度百分比（SAO2%）。烯丙哌三嗪和乙酰唑胺在睡眠期间均提高了动脉血氧饱和度百分比，不过烯丙哌三嗪增加了周期性呼吸，而乙酰唑胺减少了周期性呼吸。烯丙哌三嗪使HVR（每分通气量变化/动脉血氧饱和度变化百分比）加倍（p < 0.05），但乙酰唑胺未使其改变。HVR与周期性呼吸呈正相关（p < 0.05）。我们得出结论，高海拔睡眠期间的周期性呼吸与低氧通气反应有关，并且乙酰唑胺在改善周期性呼吸方面是比烯丙哌三嗪更优的药物。
