Department of Sense Organs, Otorhinolaryngology Section, Sapienza University of Rome, Policlinico Umberto I, Viale dell'Università, 33, 00161, Rome, Italy.
I.R.C.C.S. San Raffaele Pisana, Rome, Italy.
Neurol Sci. 2022 Sep;43(9):5411-5419. doi: 10.1007/s10072-022-06175-9. Epub 2022 Jun 4.
Oropharyngeal dysphagia (OD) screening tests have improved patient management; however, the complex applicability and high percentage of false negatives do not allow these tests to be considered completely reliable if not supported by an instrumental investigation. The aim of the present study is to evaluate an OD screening test, the Dysphagia Standard Assessment (DSA®) with different volumes and viscosities.
Prospective study of 72 patients evaluated for suspected OD through a double-blind methodology conducted by two operators. All patients underwent fiberoptic endoscopic evaluation of swallowing (FEES) as a reference test and a separate DSA® test. DSA® was performed by administering boluses with different viscosities, with the signal of interruption of the test being: onset of the cough reflex, wet voice after swallowing, and/or desaturation of O2 ≥ 5%. The Penetration-Aspiration Scale (PAS) was evaluated by FEES. The cut-off identified to diagnose OD was PAS ≥ 3.
The test showed an accuracy of 82%, a sensitivity of 0.93 (95% C.I. 0.84-0.97), and a specificity of 0.78 (95% C.I. 0.67-0.87); positive predictive value 0.55 (95% C.I. 0.43-0.67); negative predictive value 0.97 (95% C.I. 0.90-0.99), positive likelihood ratio 4.37 (95% C.I. 3.6-5.2); likelihood negative ratio 0.08 (95% C.I. 0.06-0.09).
According to the preliminary results, the test showed good outcomes in determining the presence or absence of OD with a wide spectrum of applicability with some limitations that could be overcome by the selection of a target population. For this reason, a flowchart to address patient eligibility was developed.
口咽吞咽障碍(OD)筛查测试改善了患者管理;然而,如果没有仪器检查的支持,这些测试的复杂适用性和高假阴性率使得它们不能被完全认为是可靠的。本研究旨在评估一种 OD 筛查测试,即不同容量和粘度的吞咽障碍标准评估(DSA®)。
通过两名操作人员进行的双盲方法对 72 例疑似 OD 患者进行前瞻性研究。所有患者均接受纤维内镜吞咽评估(FEES)作为参考测试和单独的 DSA®测试。DSA®通过给予不同粘度的射流进行,测试中断的信号为:咳嗽反射开始、吞咽后湿音和/或 O2 饱和度下降≥5%。通过 FEES 评估渗透-吸入量表(PAS)。诊断 OD 的截定点为 PAS≥3。
该测试的准确性为 82%,灵敏度为 0.93(95%置信区间 0.84-0.97),特异性为 0.78(95%置信区间 0.67-0.87);阳性预测值为 0.55(95%置信区间 0.43-0.67);阴性预测值为 0.97(95%置信区间 0.90-0.99),阳性似然比为 4.37(95%置信区间 3.6-5.2);阴性似然比为 0.08(95%置信区间 0.06-0.09)。
根据初步结果,该测试在确定 OD 的存在或不存在方面表现出良好的结果,具有广泛的适用性,但存在一些限制,通过选择目标人群可以克服这些限制。因此,开发了一个流程图来确定患者的资格。