Department of Stomatology, Shanghai Fifth People's Hospital, Fudan University, 801 Heqing Road, Minhang District, Shanghai, 200240, China.
Central Laboratory, Shanghai Fifth People's Hospital, Fudan University, Shanghai, 200240, China.
Odontology. 2022 Oct;110(4):747-758. doi: 10.1007/s10266-022-00718-4. Epub 2022 Jun 4.
The aim is to analyze the relationship and significance of the FOS, FOSB, Suppressors of cytokine signaling (SOCS), and hypoxia-inducible factor 1 (HIF1) gene loci and their polymorphisms with periodontitis and osteopenia in the Chinese population. In this case-control study, data on questionnaires, periodontal examination, bone mineral density, and FOS, FOSB, SOCS3, and HIF1 gene loci and their polymorphisms were obtained from 474 participants. The data were analyzed using the analysis of variance, Kruskal-Wallis test, χ test, and logistic regression. The incidence of osteopenia was significantly increased in patients with periodontitis compared to controls (58.6 vs. 34.4%, P < 0.001). Accordingly, the risk was increased 2.21-fold compared with controls (95% CI 2.09-4.95). Osteopenia patients had a significantly higher risk of periodontitis than patients with normal bone density (OR = 3.22, 95% CI 2.09-4.94). There were significant positive associations between FOSB and SOCS3 polymorphisms and periodontitis and osteopenia susceptibility. Individuals carrying the G/G genotype of the FOSB gene rs708905 locus had an increased risk of periodontitis (OR = 5.06, 95% CI 2.36-10.86) and osteopenia (OR = 3.26, 95% CI 1.34-7.96). Compared with the C/C genotype, the A/A genotype of the FOSB rs8105114 locus was associated with a significantly higher risk of periodontitis (OR = 2.14, 95% CI 1.02-4.53) and osteopenia (OR = 2.85, 95% CI 1.12-7.22). Compared with the A/A genotype, the risk of periodontitis in the G/G genotype of the SOCS3 rs7207782 locus was increased 3.10-fold (P < 0.001), and the risk of osteopenia was increased 2.01-fold (P = 0.023). There was a bidirectional relationship between periodontitis and osteopenia. The rs708905 G/G and rs8105114 A/A genotypes of FOSB and the rs7207782 G/G genotype of SOCS3 were risk factors for both periodontitis and osteopenia in the Chinese population, which could increase knowledge about disease‑specific and cross‑disease genetic pattern.
目的是分析中国人群中 FOS、FOSB、细胞因子信号转导抑制剂（SOCS）和缺氧诱导因子 1（HIF1）基因座及其多态性与牙周炎和骨质疏松症的关系和意义。在这项病例对照研究中，我们从 474 名参与者中获得了问卷、牙周检查、骨密度以及 FOS、FOSB、SOCS3 和 HIF1 基因座及其多态性的数据。使用方差分析、Kruskal-Wallis 检验、卡方检验和逻辑回归对数据进行分析。与对照组相比，牙周炎患者骨质疏松症的发生率明显升高（58.6%比 34.4%，P<0.001）。相应地，与对照组相比，风险增加了 2.21 倍（95%CI 2.09-4.95）。骨质疏松症患者发生牙周炎的风险明显高于骨密度正常的患者（OR=3.22，95%CI 2.09-4.94）。FOSB 和 SOCS3 多态性与牙周炎和骨质疏松症易感性之间存在显著的正相关关系。FOSB 基因 rs708905 位点携带 G/G 基因型的个体患牙周炎的风险增加（OR=5.06，95%CI 2.36-10.86）和骨质疏松症（OR=3.26，95%CI 1.34-7.96）。与 C/C 基因型相比，FOSB rs8105114 位点的 A/A 基因型与牙周炎（OR=2.14，95%CI 1.02-4.53）和骨质疏松症（OR=2.85，95%CI 1.12-7.22）的风险显著增加有关。与 A/A 基因型相比，SOCS3 rs7207782 位点 G/G 基因型的个体患牙周炎的风险增加了 3.10 倍（P<0.001），患骨质疏松症的风险增加了 2.01 倍（P=0.023）。牙周炎和骨质疏松症之间存在双向关系。FOSB 的 rs708905 G/G 和 rs8105114 A/A 基因型以及 SOCS3 的 rs7207782 G/G 基因型是中国人群牙周炎和骨质疏松症的危险因素，这可以增加对疾病特异性和跨疾病遗传模式的了解。
