从接骨木镰刀菌NRRL 13495培养物中高产制备蛇形菌素和三乙酰氧基蛇形菌素。
Preparation of scirpentriol and triacetoxyscirpenol in good yield from cultures of Fusarium sambucinum NRRL 13495.
作者信息
Richardson K E, Hamilton P B
出版信息
Appl Environ Microbiol. 1987 Feb;53(2):457-9. doi: 10.1128/aem.53.2.457-459.1987.
Abstract
Crude extracts of filtrates of cultures of Fusarium sambucinum NRRL 13495 were acetylated or hydrolyzed. After chromatography on cartridge columns of silica gel and recrystallization three times from mixtures of ethyl acetate and hexane, 3,4,15-triacetoxyscirpenol (435 +/- 10 mg/liter of filtrate; mean +/- standard error [n = 3]) and the parent alcohol scirpentriol were isolated (261 +/- 29 mg/liter of filtrate; mean +/- standard error [n = 3]) in 68 and 53% yield for a 130- and 14-fold improvement, respectively, over prior reports.
摘要
对镰刀菌NRRL 13495培养物滤液的粗提物进行乙酰化或水解处理。在硅胶柱色谱上进行分离，并从乙酸乙酯和己烷的混合物中重结晶三次后，分离出了3,4,15 - 三乙酰氧基司替泊醇（每升滤液435±10毫克；平均值±标准误[n = 3]）和母体醇司替泊三醇（每升滤液261±29毫克；平均值±标准误[n = 3]），产率分别为68%和53%，相较于之前的报道分别提高了130倍和14倍。
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