Long Hairong, Xia Xianghua, Liao Suqi, Wu Tao, Wang Lijun, Chen Qianping, Wei Shugen, Gu Xiaoyu, Zhu Zhenjun
Guangxi Botanical Garden of Medicinal Plants, No. 189, Nanning, China.
Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin, China.
Front Nutr. 2022 May 18;9:903218. doi: 10.3389/fnut.2022.903218. eCollection 2022.
fruit, a novel fruit resource, has attracted wide interest, but the physicochemical characteristics and biological activities of its polysaccharides remain unclear. This study investigated the physicochemical properties of a polysaccharide extracted from fruit polysaccharide (KCFP) and evaluated its antioxidant and hypolipidaemic activities and . KCFP is an amorphous, thermally stable pectin heteropolysaccharide with an average molecular weight of 204.6 kDa that is mainly composed of mannose, rhamnose, glucose, galactose, xylose, arabinose, galacturonic acid (molar percentage >70%) and glucuronic acid. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radical scavenging assays and an iron reducing antioxidant power assay showed that KCFP has strong antioxidant capacity, while the bile acid binding assay showed that KCFP has hypolipidaemic potential . The antioxidant and hypolipidaemic activities of KCFP were further evaluated in high-fat diet-induced hyperlipidaemic mice. KCFP significantly increased the activities of superoxide dismutase, glutathione peroxidase and catalase, decreased the malondialdehyde content, significantly reduced the total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) levels, and increased the amount of high-density lipoprotein cholesterol (HDL-C). These findings suggest that KCFP could be used as a functional food to remedy oxidative damage and hyperlipidaemia.
[水果名称]，一种新型水果资源，已引起广泛关注，但其多糖的理化特性和生物活性仍不清楚。本研究调查了从[水果名称]中提取的多糖（KCFP）的理化性质，并评估了其抗氧化和降血脂活性。KCFP是一种无定形、热稳定的果胶杂多糖，平均分子量为204.6 kDa，主要由甘露糖、鼠李糖、葡萄糖、半乳糖、木糖、阿拉伯糖、半乳糖醛酸（摩尔百分比>70%）和葡萄糖醛酸组成。2,2-二苯基-1-苦基肼（DPPH）和2,2'-联氮-双-（3-乙基苯并噻唑啉-6-磺酸）（ABTS）自由基清除试验以及铁还原抗氧化能力试验表明，KCFP具有较强的抗氧化能力，而胆汁酸结合试验表明KCFP具有降血脂潜力。在高脂饮食诱导的高脂血症小鼠中进一步评估了KCFP的抗氧化和降血脂活性。KCFP显著提高了超氧化物歧化酶、谷胱甘肽过氧化物酶和过氧化氢酶的活性降低了丙二醛含量，显著降低了总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-C）水平，并增加了高密度脂蛋白胆固醇（HDL-C）的含量。这些发现表明，KCFP可作为一种功能性食品来修复氧化损伤和高脂血症。
