Guo Peng, Chen Meng, Wang Wenzhao, Li Qiuyun, Chen Xinyu, Liang Jiayue, He Yiyang, Wu Yanli
Department of Organic Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150081, China.
Molecules. 2024 Apr 12;29(8):1751. doi: 10.3390/molecules29081751.
is a natural medicinal herb with diverse bioactivities. Certain extracts from this herb have been confirmed to possess anti-glycolipid metabolic disorder activity. To further develop its utility value and explore its potential in combating glycolipid metabolic disorders, we designed a series of experiments to investigate the structure, antioxidant activity, and anti-glycolipid metabolic disorder activity of polysaccharides. In this study, we extracted and purified polysaccharides from and thoroughly analyzed their structure using various techniques, including NMR, methylation analysis, and surface-enhanced Raman spectroscopy. We investigated the hypolipidemic and anti-glycolipid metabolism disorder activity of polysaccharides for the first time utilizing oleic acid (OA) and advanced glycation end products (AGEs) as inducers. Additionally, the antioxidant activity of polysaccharides was assessed in vitro. These findings lay the groundwork for future investigations into the potential application of polysaccharides as an intervention for preventing and treating diabetes.
是一种具有多种生物活性的天然药草。已证实该草药的某些提取物具有抗糖脂代谢紊乱活性。为了进一步开发其利用价值并探索其在对抗糖脂代谢紊乱方面的潜力，我们设计了一系列实验来研究多糖的结构、抗氧化活性和抗糖脂代谢紊乱活性。在本研究中，我们从[草药名称]中提取并纯化了多糖，并使用包括核磁共振（NMR）、甲基化分析和表面增强拉曼光谱等各种技术对其结构进行了全面分析。我们首次利用油酸（OA）和晚期糖基化终产物（AGEs）作为诱导剂，研究了[草药名称]多糖的降血脂和抗糖脂代谢紊乱活性。此外，还在体外评估了[草药名称]多糖的抗氧化活性。这些发现为未来研究[草药名称]多糖作为预防和治疗糖尿病的干预措施的潜在应用奠定了基础。
