Seguro Charmaine Kue, Demory Beckler Michelle, Kesselman Marc M
Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA.
Microbiology and Immunology, Nova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine, Fort Lauderdale, USA.
Cureus. 2022 May 3;14(5):e24704. doi: 10.7759/cureus.24704. eCollection 2022 May.
Inflammasomes are intracellular, multi-protein signaling complexes of the innate immune system that activate and control inflammatory responses in nucleated cells. Among these inflammasomes, the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome, a cytosolic sensor that modulates inflammatory responses in nucleated cells upon detection of various danger signals and microbial motifs, has been shown to a play a role in a wide range of pathologies and associated symptomatologies, including psoriasis and associated fatigue. Activation of the NLRP3 inflammasome can lead to caspase-1-dependent release of inflammatory cytokines, which potentially act on surrounding cells and may contribute to symptoms of fatigue. In this review, we will present recent developments in NLRP3 inflammasome research as it relates to psoriasis and fatigue, with a focus on the intracellular signaling pathways governing NLRP3 inflammasome regulation and promising pharmacological therapeutics that inhibit NLRP3 inflammasomal pathways.
炎性小体是先天性免疫系统的细胞内多蛋白信号复合物，可激活并控制有核细胞中的炎症反应。在这些炎性小体中，含NOD、LRR和pyrin结构域的蛋白3（NLRP3）炎性小体是一种胞质传感器，在检测到各种危险信号和微生物基序后可调节有核细胞中的炎症反应，已被证明在包括银屑病及相关疲劳在内的多种病理状况和相关症状中发挥作用。NLRP3炎性小体的激活可导致炎症细胞因子的半胱天冬酶-1依赖性释放，这些细胞因子可能作用于周围细胞，并可能导致疲劳症状。在本综述中，我们将介绍NLRP3炎性小体研究中与银屑病和疲劳相关的最新进展，重点关注调控NLRP3炎性小体的细胞内信号通路以及抑制NLRP3炎性小体途径的有前景的药物治疗方法。
