Yazji John H, Garg Pankaj, Wadiwala Ishaq, Alomari Mohammad, Alamouti-Fard Emad, Hussain Md Walid Akram, Jacob Samuel
Cardiothoracic Surgery, Mayo Clinic, Jacksonville, USA.
Cureus. 2022 May 30;14(5):e25485. doi: 10.7759/cureus.25485. eCollection 2022 May.
Heart transplant surgery is considered the destination therapy for end-stage heart disease. Unfortunately, many patients in the United States of America who are eligible candidates for transplants cannot undergo surgery due to donor shortage. In addition, some donors' hearts are being labeled as unacceptable for transplant surgery because of the rigorous and restricted rules placed on the approval process of using a donor's heart. Over the last few decades, the rising discrepancy between the scarcity of donor hearts and the demand for such organs has led to the discussion of expanding the donor heart selection criteria. A softer view on using marginal hearts for transplants would help those on the waitlist to receive a heart transplant. Marginal hearts that contain the hepatitis c virus (HCV), COVID-19, older age, or repairable heart defects have become viable options to use for a heart transplant. Also, the prioritization based on the new heart allocation system would help efficiently decide which recipients would be the first to get a donor's heart. Recently there has been a consensus to broaden the eligibility of donor's hearts by accepting valvular abnormalities, coronary artery disease, and congenital abnormalities. This review highlights some of those expansions in selection criteria in particular using repairable hearts, which could be fixed in the operating room on the back table before transplantation.
心脏移植手术被视为终末期心脏病的最终治疗手段。不幸的是,美国许多符合移植条件的患者由于供体短缺而无法接受手术。此外,由于使用供体心脏的审批过程严格且受限,一些供体的心脏被标记为不适合移植手术。在过去几十年里,供体心脏的稀缺与对这类器官的需求之间日益增大的差距引发了关于扩大供体心脏选择标准的讨论。对使用边缘性心脏进行移植持更宽松的观点将有助于等待名单上的人接受心脏移植。含有丙型肝炎病毒(HCV)、新冠病毒、年龄较大或可修复心脏缺陷的边缘性心脏已成为可用于心脏移植的可行选择。此外,基于新的心脏分配系统进行优先排序将有助于有效决定哪些受者将首先获得供体心脏。最近,人们已达成共识,通过接受瓣膜异常、冠状动脉疾病和先天性异常来扩大供体心脏的合格范围。本综述特别强调了选择标准中的一些扩展内容,尤其是使用可修复心脏,即在移植前可在手术台上修复的心脏。