Tchang Beverly G, Aras Mohini, Wu Alan, Aronne Louis J, Shukla Alpana P
Department of Medicine Division of Endocrinology, Diabetes and Metabolism Comprehensive Weight Control Center Weill Cornell Medicine New York New York USA.
Division of Biostatistics and Epidemiology Department of Healthcare Policy & Research Weill Cornell Medicine New York New York USA.
Obes Sci Pract. 2021 Dec 2;8(3):320-327. doi: 10.1002/osp4.575. eCollection 2022 Jun.
To determine the association of anti-obesity medications (AOMs) with weight loss maintenance over 2 years.
This is a retrospective observational cohort study of adults treated for obesity between 1 April 2014 and 1 April 2016 at a tertiary academic weight management center and who completed 2 years of follow-up. Main outcome measures were mean percent weight loss, percent of individuals who achieved clinically significant long-term weight loss (≥5% weight loss over 2 years), and long-term weight loss maintenance (achievement of ≥5% weight loss at 1 year and maintenance of the ≥5% reduction for the second year).
Of the 1566 new patients, 421 completed 1- and 2-year follow-up appointments. Patients were mostly female and on average 51 years old; they weighed 100.1 kg and had a BMI of 35.8 kg/m at initial visit. Mean weight losses at 1 and 2 years were 10.1% and 10.2%, respectively. The proportion of patients who experienced ≥5% weight loss was 75.5% at 1 year and 72.9% at 2 years. Long-term weight loss maintenance was achieved by 65.3% of patients. Almost all (96.2%) were on ≥1 AOM at 2 years, with metformin, phentermine, and topiramate among the most prescribed. AOM usage and older age demonstrated trends toward predicting weight loss maintenance over 2 years.
Long-term weight loss maintenance was observed among adults with medically managed obesity who completed 2 years of follow-up.
确定抗肥胖药物（AOMs）与两年内体重减轻维持情况之间的关联。
这是一项回顾性观察队列研究，研究对象为2014年4月1日至2016年4月1日在一家三级学术体重管理中心接受肥胖治疗并完成两年随访的成年人。主要结局指标为平均体重减轻百分比、实现临床显著长期体重减轻（两年内体重减轻≥5%）的个体百分比，以及长期体重减轻维持情况（1年时体重减轻≥5%且第二年维持≥5%的减重幅度）。
1566名新患者中，421人完成了1年和2年的随访预约。患者大多为女性，平均年龄51岁；初诊时体重为100.1千克，体重指数为35.8千克/平方米。1年和2年时的平均体重减轻分别为10.1%和10.2%。体重减轻≥5%的患者比例在1年时为75.5%，在2年时为72.9%。65.3%的患者实现了长期体重减轻维持。两年时几乎所有患者（96.2%）都在使用≥1种AOM，其中二甲双胍、苯丁胺和托吡酯是最常开具的药物。AOM的使用和年龄较大显示出预测两年内体重减轻维持情况的趋势。
在完成两年随访的接受医学管理的肥胖成年人中观察到了长期体重减轻维持情况。
