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SPDL1过表达与食管癌的18F-FDG PET/CT代谢参数、预后及进展相关。

SPDL1 Overexpression Is Associated With the 18F-FDG PET/CT Metabolic Parameters, Prognosis, and Progression of Esophageal Cancer.

作者信息

Liu Hua-Song, Guo Qiang, Yang Heng, Zeng Min, Xu Li-Qiang, Zhang Qun-Xian, Liu Hua, Guo Jia-Long, Zhang Jun

机构信息

Department of Cardiothoracic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, China.

出版信息

Front Genet. 2022 May 18;13:798020. doi: 10.3389/fgene.2022.798020. eCollection 2022.

DOI:10.3389/fgene.2022.798020
PMID:35664322
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9157543/
Abstract

Esophageal cancer (ESCA) is one of the common malignant tumors. The roles and signaling mechanisms of spindle apparatus coiled-coil protein 1 (SPDL1) in ESCA progression have not been reported previously. Therefore, the expression levels and potential clinical roles of were investigated using data from multiple databases and tissue samples of 53 ESCA patients who underwent 18F-FDG positron emission tomography (PET)/computed tomography (CT) before therapy. The signaling mechanisms of SPDL1 involved in ESCA progression were investigated via bioinformatics analysis. The effects of SPDL1 on the growth and migration of ESCA cells were investigated using CCK-8, Edu, and transwell assays. was upregulated in ESCA tissues. Increased expression was associated with age, grade, drinking history, cancer stage, lymph node metastasis, TP53 mutation, and poor prognosis in patients with ESCA. overexpression was significantly correlated with SUVmax, SUVmean, and TLG of PET/CT. silencing inhibited cell proliferation, migration, and invasion. was significantly enriched in cell cycle, spliceosome, DNA replication, and other processes. The hub genes of a constructed protein-protein interaction network included CDK1, BUB1, CCNB1, BUB1B, CCNA2, CDC20, MAD2L1, AURKB, NDC80, and PLK1, which were related to expression. The findings of this study suggest that SPDL1 may serve as a biomarker of ESCA prognosis.

摘要

食管癌（ESCA）是常见的恶性肿瘤之一。纺锤体装置卷曲螺旋蛋白1（SPDL1）在ESCA进展中的作用和信号机制此前尚未见报道。因此，利用多个数据库的数据以及53例接受治疗前18F-FDG正电子发射断层扫描（PET）/计算机断层扫描（CT）的ESCA患者的组织样本，研究了SPDL1的表达水平及其潜在的临床作用。通过生物信息学分析研究了SPDL1参与ESCA进展的信号机制。使用CCK-8、Edu和Transwell实验研究了SPDL1对ESCA细胞生长和迁移的影响。SPDL1在ESCA组织中上调。SPDL1表达增加与ESCA患者的年龄、分级、饮酒史、癌症分期、淋巴结转移、TP53突变及预后不良相关。SPDL1过表达与PET/CT的SUVmax、SUVmean和TLG显著相关。SPDL1沉默抑制细胞增殖、迁移和侵袭。SPDL1在细胞周期、剪接体、DNA复制等过程中显著富集。构建的蛋白质-蛋白质相互作用网络的枢纽基因包括CDK1、BUB1、CCNB1、BUB1B、CCNA2、CDC20、MAD2L1、AURKB、NDC80和PLK1，它们与SPDL1表达相关。本研究结果表明，SPDL1可能作为ESCA预后的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13bb/9157543/97f46bcfcba3/fgene-13-798020-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13bb/9157543/40a5c47ceed1/fgene-13-798020-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13bb/9157543/e59057c3d9cd/fgene-13-798020-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13bb/9157543/9f0f849322ca/fgene-13-798020-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13bb/9157543/7e06b44a8c09/fgene-13-798020-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13bb/9157543/7a06706e6bc9/fgene-13-798020-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13bb/9157543/8585546799ce/fgene-13-798020-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13bb/9157543/8af533dff384/fgene-13-798020-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13bb/9157543/68d612e74dd1/fgene-13-798020-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13bb/9157543/97f46bcfcba3/fgene-13-798020-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13bb/9157543/40a5c47ceed1/fgene-13-798020-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13bb/9157543/e59057c3d9cd/fgene-13-798020-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13bb/9157543/9f0f849322ca/fgene-13-798020-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13bb/9157543/7e06b44a8c09/fgene-13-798020-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13bb/9157543/7a06706e6bc9/fgene-13-798020-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13bb/9157543/8585546799ce/fgene-13-798020-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13bb/9157543/8af533dff384/fgene-13-798020-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13bb/9157543/68d612e74dd1/fgene-13-798020-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13bb/9157543/97f46bcfcba3/fgene-13-798020-g009.jpg

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