基于数学模型和横断面研究的解脲脲原体影响精子质量的风险预测。

Risk Prediction of Ureaplasma urealyticum Affecting Sperm Quality Based on Mathematical Model and Cross-Sectional Study.

机构信息

The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.

Department of Andrology, NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Human Sperm Bank of Guangdong Province, Guangzhou 510060, China.

出版信息

Comput Math Methods Med. 2022 May 25;2022:2498306. doi: 10.1155/2022/2498306. eCollection 2022.

DOI:10.1155/2022/2498306

PMID:35664640

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9159871/

Abstract

OBJECTIVE

To explore the risk of Ureaplasma urealyticum () affecting sperm quality.

METHODS

Prospective cross-sectional study was conducted. In total, 340 semen samples were collected. According to whether they were infected with UU, the samples were divided into the UU-positive group () and UU-negative group (). The patients with UU-positive were followed up to obtain treatment and collected the semen again after treatment. The semen characteristics and sperm parameters were detected and compared, and the relationship of UU and the sperm quality was analyzed by mathematical models.

RESULTS

There were 104 UU-positive semen samples in all, with an overall infection rate of 30.6%, which was highest in 31 to 40-year-old men, and over 40-year-old men were the lowest. The pH, PR, VCL, VSL, and STR in the observation group were significantly lower than those in the control group ( < 0.001), while SV, NP, and WOB were significantly higher ( < 0.001). After treatment, the pH, VSL, LIN, WOB, and STR in the observation group were significantly higher than before ( < 0.001), while SV and VCL were significantly lower ( < 0.001). UU infection was closely correlated with pH, PR, NP, VCL, VSL, WOB, and STR. During the treatment, pH, PR, VSL, WOB, and STR increased, but NP and VCL decreased. 7 major factors that would affect SQ were extracted, of which VAP, LIN, and UU were the first three main factors. The risk of SQ declining after UU infection increased nearly twice with the change of PR and VCL and increased 0.08 times with STR.

CONCLUSION

UU may approximately double the risk of altering the sperm's curvilinear movement rate and straightness to affect the sperm quality.

摘要

目的

探讨解脲脲原体（Ureaplasma urealyticum，UU）对精子质量的影响风险。

方法

采用前瞻性病例对照研究。共收集 340 份精液标本。根据是否感染 UU，将标本分为 UU 阳性组（）和 UU 阴性组（）。对 UU 阳性患者进行随访并获得治疗，治疗后再次采集精液。检测并比较精液特征和精子参数，通过数学模型分析 UU 与精子质量的关系。

结果

共检出 UU 阳性精液标本 104 份，总感染率为 30.6%，其中 31~40 岁年龄段感染率最高，41 岁以上年龄段感染率最低。观察组 pH、PR、VCL、VSL、STR 显著低于对照组（<0.001），SV、NP、WOB 显著高于对照组（<0.001）。治疗后观察组 pH、VSL、LIN、WOB、STR 显著高于治疗前（<0.001），SV、VCL 显著低于治疗前（<0.001）。UU 感染与 pH、PR、NP、VCL、VSL、WOB、STR 密切相关。治疗过程中，pH、PR、VSL、WOB、STR 升高，NP、VCL 降低。提取出影响精子质量的 7 个主要因素，其中 VAP、LIN、UU 是前 3 个主要因素。UU 感染后精子质量下降的风险随 PR 和 VCL 的变化增加近两倍，随 STR 的增加增加 0.08 倍。