系统生物学中的计算模型：标准、传播和最佳实践。
Computational models in systems biology: standards, dissemination, and best practices.
机构信息
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL 32610, United States; Department of Psychiatry, University of Florida, Gainesville, FL 32610, United States.
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL 32610, United States.
出版信息
Curr Opin Biotechnol. 2022 Jun;75:102702. doi: 10.1016/j.copbio.2022.102702. Epub 2022 Feb 23.
Abstract
Mathematical and computational models are a key technology in systems biology. Progress in the field depends on the replicability and reproducibility of their properties and behavior. For this, an essential requirement is a set of clear standards for model specification and dissemination. This review covers existing standards, and it highlights the most important areas where further work is required. This includes the specification of agent-based models, an increasingly common modeling approach.
摘要
数学和计算模型是系统生物学的关键技术。该领域的进展取决于其特性和行为的可重复性和可再现性。为此，一个基本要求是为模型规范和传播制定一套明确的标准。本综述涵盖了现有的标准，并强调了在哪些方面需要进一步开展工作，这包括日益流行的基于主体的模型的规范制定。
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