Doroftei Bogdan, Ilie Ovidiu-Dumitru, Armeanu Theodora, Anton Emil, Scripcariu Ioana, Maftei Radu
Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", University Street, no 16, 700115 Iasi, Romania.
Clinical Hospital of Obstetrics and Gynecology "Cuza Voda", Cuza Voda Street, no 34, 700038 Iasi, Romania.
Medicina (Kaunas). 2021 Feb 26;57(3):211. doi: 10.3390/medicina57030211.
Ureaplasma urealyticum (UU) and Mycoplasma hominis (MH) are two commensal microorganisms that form the urogenital microbiota. Under a state of dysbiosis, both bacteria cause intrauterine infection. Therefore, the purpose of the present study was to analyze the prevalence of UU and MH among four hundred and eleven infertile women. Women between thirty and thirty-five years old were the most affected group, followed by those that were 25 and 30 years old, respectively. Cumulatively, the prevalence of single UU and MH, and coinfection, was 28.46% ( = 117), ( = 2) 0.48%, and 2.91% ( = 12), respectively, with an overall detection rate of 31.87% ( = 131). To assess the associated drug susceptibility, endocervical samples were unequally sent to Regina Maria ( = 281) and Synevo ( = 130) laboratories for further analyses. Pristinamycin (100% vs. 100%) and Josamycin (100% vs. 98.00%) were the most efficient antibiotics in eradicating UU and MH, several others also displaying a high efficiency, among which can be mentioned Doxycycline (98.23%), Minocycline (96.00%), Tetracycline (96.48% vs. 68.00%), and Erythromycin (70.17% vs. 92.00%). Based on antibiograms, Clarithromycin (88.00%), Roxithromycin (88.00%), Levofloxacin (82.00%), and Azithromycin (78.94%) can be further used in treating such infections. On the other hand, Clindamycin (4.00%) and Ciprofloxacin (12.27% vs. 2.00%) are no longer viable because both UU and MH display an intermediate response towards gained resistance. Interestingly, the efficiency of Ofloxacin (22.79% vs. 60.00%) was conflicting, this possibly suggesting a transient stage to a gradual adaptability of these microorganisms to Ofloxacin. The most susceptible age groups in each case were women that were between twenty and forty years old. It can be concluded that four antibiotics can be safely used for treating UU, MH, or dual infections whose efficiency was over 95%.
解脲脲原体（UU）和人型支原体（MH）是构成泌尿生殖微生物群的两种共生微生物。在生态失调状态下，这两种细菌都会引起宫内感染。因此，本研究的目的是分析411名不孕妇女中UU和MH的流行情况。30至35岁的女性是受影响最大的群体，其次分别是25至30岁的女性。累积来看，单一UU和MH的流行率以及合并感染率分别为28.46%（n = 117）、0.48%（n = 2）和2.91%（n = 12），总体检出率为31.87%（n = 131）。为评估相关药物敏感性，宫颈样本被不均衡地送往Regina Maria实验室（n = 281）和Synevo实验室（n = 130）进行进一步分析。 pristinamycin（100%对100%）和交沙霉素（对UU，100%对98.00%）是根除UU和MH最有效的抗生素，其他几种抗生素也显示出高效，其中可提及多西环素（98.23%）、米诺环素（96.00%）、四环素（96.48%对68.00%）和红霉素（70.17%对92.00%）。根据药敏谱，克拉霉素（88.00%）、罗红霉素（88.00%）、左氧氟沙星（82.00%）和阿奇霉素（78.94%）可进一步用于治疗此类感染。另一方面，克林霉素（4.00%）和环丙沙星（对UU，12.27%对2.00%）不再适用，因为UU和MH对获得性耐药均表现出中度反应。有趣的是，氧氟沙星的有效性存在矛盾（22.79%对60.00%），这可能表明这些微生物对氧氟沙星的适应性处于逐渐变化的过渡阶段。每种情况下最易感的年龄组是20至40岁的女性。可以得出结论，四种抗生素可安全用于治疗效率超过95%的UU、MH或双重感染。
