Titcomb Tyler J, Bao Wei, Du Yang, Liu Buyun, Snetselaar Linda G, Wahls Terry L
Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Mult Scler J Exp Transl Clin. 2022 May 30;8(2):20552173221104009. doi: 10.1177/20552173221104009. eCollection 2022 Apr-Jun.
Multiple sclerosis (MS) has been associated with increased mortality ratios, but few studies have investigated the independent association of MS with mortality.
To examine the prospective association of MS with risk of mortality in a nationally representative sample of U.S. adults.
This prospective study included 23,053 adults aged 45-79 years who participated in the National Health Interview Survey in 2002 and 2008. Physician-diagnosed MS was reported by participants during household interviews. These participants were linked to death records from survey date through December 31, 2015.
Among the 23,053 participants included in this study, 120 reported a physician's diagnosis of MS, with a higher prevalence in females (0.85%) than in males (0.31%). During on average 9.4 years (maximum 13.8 years) of observation, 4208 deaths occurred. After adjustment for age, sex, race/ethnicity, socioeconomic factors, lifestyle factors, and BMI, participants with MS had an 80% higher risk of mortality (HR 1.80; 95% CI, 1.11-2.92), compared with those without MS. The association remained significant (HR 1.75; 95% CI, 1.07-2.87) after further adjustment for baseline diabetes, cardiovascular disease, chronic lung disease, and cancer.
In this nationally representative sample of U.S. adults, MS was associated with an increased risk of mortality.
多发性硬化症（MS）与死亡率升高有关，但很少有研究调查MS与死亡率之间的独立关联。
在美国成年人的全国代表性样本中，研究MS与死亡风险之间的前瞻性关联。
这项前瞻性研究纳入了23,053名年龄在45 - 79岁之间的成年人，他们分别在2002年和2008年参加了国家健康访谈调查。参与者在家庭访谈中报告了医生诊断的MS。这些参与者与从调查日期到2015年12月31日的死亡记录相链接。
在本研究纳入的23,053名参与者中，120人报告医生诊断为MS，女性患病率（0.85%）高于男性（0.31%）。在平均9.4年（最长13.8年）的观察期内，发生了4208例死亡。在调整年龄、性别、种族/民族、社会经济因素、生活方式因素和BMI后，与无MS的参与者相比，患有MS的参与者死亡风险高80%（HR 1.80；95% CI，1.11 - 2.92）。在进一步调整基线糖尿病、心血管疾病、慢性肺病和癌症后，这种关联仍然显著（HR 1.75；95% CI，1.07 - 2.87）。
在这个美国成年人的全国代表性样本中，MS与死亡风险增加有关。
