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硫酸镁联合拉贝洛尔治疗妊娠高血压的子宫超声多普勒血流动力学:基于经验小波变换算法。

Uterine Ultrasound Doppler Hemodynamics of Magnesium Sulfate Combined with Labetalol in the Treatment of Pregnancy-Induced Hypertension Using Empirical Wavelet Transform Algorithm.

机构信息

Department of Obstetrics, Taiyuan Maternal and Child Health Hospital, Taiyuan 030020, Shanxi, China.

出版信息

Comput Intell Neurosci. 2022 May 26;2022:7951342. doi: 10.1155/2022/7951342. eCollection 2022.

Abstract

The aim of this study was to explore the hemodynamic changes of magnesium sulfate combined with labetalol in the treatment of pregnancy-induced hypertension (PIH) under Doppler uterine ultrasound based on the empirical wavelet transform (EWT) algorithm. 500 patients with PIH in the hospital were selected and randomly divided into the control group ( = 250) and the observation group ( = 250). The control group was treated with conventional magnesium sulfate; the observation group was given labetalol based on magnesium sulfate drip in the control group. The uterine artery blood flow simulation model was established based on the EWT algorithm and compared with a short-time Fourier transform (STFT). The normalized root mean square error (NRMSE) of the STFT method was 0.19, and the NRMSE extracted by the EWT method was 0.13. After treatment, the blood pressure index, 24-hour urinary protein, and incidence of adverse birth outcomes in the observation group were lower than those in the control group; the effective rate of the control group (90.4%) was lower than that of the observation group (97.6%); the hemodynamic indexes of the uterine artery in the observation group were lower than those in the control group, and the differences were statistically significant ( < 0.05). The estimation accuracy of the EWT method was higher than that of the traditional STFT method; the combined treatment of magnesium sulfate and labetalol in patients with PIH had a remarkable effect, which could control the blood pressure index and reduce the 24-hour urinary protein; the uterine artery Doppler ultrasound examination could change hemodynamics and improve the adverse outcomes of mothers and infants.

摘要

本研究旨在基于经验小波变换(EWT)算法探讨多普勒子宫超声下硫酸镁联合拉贝洛尔治疗妊娠高血压(PIH)的血液动力学变化。选取我院收治的 PIH 患者 500 例,随机分为对照组(n=250)和观察组(n=250)。对照组给予常规硫酸镁治疗;观察组在对照组硫酸镁滴注基础上加用拉贝洛尔。基于 EWT 算法建立子宫动脉血流模拟模型,并与短时傅里叶变换(STFT)进行比较。STFT 方法的归一化均方根误差(NRMSE)为 0.19,EWT 方法提取的 NRMSE 为 0.13。治疗后,观察组的血压指标、24 小时尿蛋白和不良出生结局发生率均低于对照组;对照组有效率(90.4%)低于观察组(97.6%);观察组子宫动脉血流动力学指标均低于对照组,差异有统计学意义(<0.05)。EWT 方法的估计准确性高于传统的 STFT 方法;硫酸镁联合拉贝洛尔治疗 PIH 患者的效果显著,可控制血压指标,减少 24 小时尿蛋白;子宫动脉多普勒超声检查可改变血液动力学,改善母婴不良结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1f1/9162808/721bfb7196c4/CIN2022-7951342.001.jpg

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