Migliori M E, Beckman H, Channell M M
Arch Ophthalmol. 1987 Apr;105(4):473-5. doi: 10.1001/archopht.1987.01060040043028.
Sixty eyes undergoing Q-switched neodymium-YAG laser posterior capsulotomy were randomly assigned to pretreatment with either 0.5% timolol maleate or placebo. Half of the eyes in each group underwent capsulotomies performed with six 2-mJ bursts of energy, and the remaining eyes underwent capsulotomies performed with three 4-mJ bursts of energy. There was no significant difference in pressure responses between eyes treated with 2 or 4 mJ. The mean rise in intraocular pressure was significantly less in the timolol-pretreated group one hour after capsulotomy. After four hours, the difference between groups was not significant. Pretreating with timolol did not prevent late pressure rises. Nonpseudophakic eyes were more likely to sustain pressure increases greater than 10 mm than were pseudophakic eyes.
60只接受调Q钕-YAG激光后囊切开术的眼睛被随机分为两组，分别用0.5%马来酸噻吗洛尔或安慰剂进行预处理。每组中一半的眼睛接受6次2毫焦能量脉冲的囊切开术，其余眼睛接受3次4毫焦能量脉冲的囊切开术。接受2毫焦或4毫焦治疗的眼睛之间的眼压反应没有显著差异。在囊切开术后1小时，噻吗洛尔预处理组的眼压平均升高明显较少。4小时后，两组之间的差异不显著。用噻吗洛尔预处理并不能预防后期眼压升高。与人工晶状体眼相比，非人工晶状体眼更有可能承受大于10毫米汞柱的眼压升高。
