人肝脏、肾上腺、肾脏和脾脏中谷胱甘肽S-转移酶碱性、中性和酸性同工酶的发育研究。
Studies of the development of basic, neutral and acidic isoenzymes of glutathione S-transferase in human liver, adrenal, kidney and spleen.
作者信息
Faulder C G, Hirrell P A, Hume R, Strange R C
出版信息
Biochem J. 1987 Jan 1;241(1):221-8. doi: 10.1042/bj2410221.
Abstract
The ontogeny of basic, near-neutral and acidic glutathione S-transferase isoenzymes was studied by using chromatofocusing and ion-exchange chromatography. These isoenzyme sets demonstrated tissue-specific patterns of expression. For example, whereas basic isoenzymes were identified in all liver and adrenal cytosols obtained after 10 weeks gestation, these forms were not detected in kidney until 10 weeks post-natal age and in spleen until about 40 weeks post-natal age. Our data indicate that the basic monomers B1 and B2 are present in liver cytosol at 21 weeks gestation. Expression of the near-neutral isoenzymes was usually weak; for example, they were not generally expressed in liver until 30 weeks gestation, and no developmental patterns in their expression could be identified in adrenal, kidney and spleen. The acidic isoenzymes were usually strongly expressed in adrenal, kidney and spleen, although there was a decline in the level of expression in kidney after birth.
摘要
通过使用聚焦层析和离子交换色谱法研究了碱性、近中性和酸性谷胱甘肽S-转移酶同工酶的个体发生。这些同工酶组显示出组织特异性的表达模式。例如，虽然在妊娠10周后获得的所有肝脏和肾上腺胞质溶胶中都鉴定出了碱性同工酶，但直到出生后10周才在肾脏中检测到这些形式，在脾脏中直到出生后约40周才检测到。我们的数据表明，碱性单体B1和B2在妊娠21周时存在于肝脏胞质溶胶中。近中性同工酶的表达通常较弱；例如，它们通常直到妊娠30周才在肝脏中表达，并且在肾上腺、肾脏和脾脏中未发现其表达的发育模式。酸性同工酶通常在肾上腺、肾脏和脾脏中强烈表达，尽管出生后肾脏中的表达水平有所下降。
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本文引用的文献
1
Biochemical genetics of glutathione-S-transferase in man.人类谷胱甘肽-S-转移酶的生化遗传学
Am J Hum Genet. 1981 Jan;33(1):36-43.
2
Studies on the variability of glutathione S-transferase from human erythrocytes.
Clin Chim Acta. 1982 Apr 8;120(2):251-60. doi: 10.1016/0009-8981(82)90162-0.
3
The human glutathione S-transferases: studies on the tissue distribution and genetic variation of the GST1, GST2 and GST3 isozymes.人类谷胱甘肽S-转移酶：关于GST1、GST2和GST3同工酶的组织分布及基因变异的研究
Ann Hum Genet. 1984 Jan;48(1):11-20. doi: 10.1111/j.1469-1809.1984.tb00829.x.
4
Purification of human hepatic glutathione S-transferases and the development of a radioimmunoassay for their measurement in plasma.人肝谷胱甘肽S-转移酶的纯化及其血浆中含量测定的放射免疫分析方法的建立。
Clin Chim Acta. 1983 Oct 31;134(1-2):107-21. doi: 10.1016/0009-8981(83)90189-4.
5
Molecular and catalytic properties of glutathione transferase mu from human liver: an enzyme efficiently conjugating epoxides.人肝脏谷胱甘肽转移酶μ的分子与催化特性：一种高效结合环氧化物的酶
Biochemistry. 1983 Jul 19;22(15):3610-7. doi: 10.1021/bi00284a011.
6
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J Biol Chem. 1985 Sep 25;260(21):11603-10.
8
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10
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