听源性敏感大鼠血清和大脑中的胍基化合物。
Guanidino compounds in serum and brain of audiogenically sensitive rats.
作者信息
Wiechert P, Marescau B, De Deyn P, Lowenthal A
出版信息
Biomed Biochim Acta. 1986;45(10):1339-42.
The levels of 12 guanidino compounds were determined in serum and brain of audiogenically sensitive rats with and without seizures. During audiogenic seizures the serum levels of creatine are significantly decreased, while those of guanidinoacetic acid, N-alpha-acetylarginine, creatinine, gamma-guanidinobutyric acid, arginine, guanidine and methylguanidine are significantly increased. In brain only creatinine and N-alpha-acetylarginine are markedly increased during seizure. These data demonstrate noticeable modifications of the levels of guanidino compounds in the blood during audiogenic seizure and also, in parallel, a creatinine increase in serum and brain.
在有或无癫痫发作的听源性敏感大鼠的血清和脑中测定了12种胍基化合物的水平。在听源性癫痫发作期间，肌酸的血清水平显著降低，而胍基乙酸、N-α-乙酰精氨酸、肌酐、γ-胍基丁酸、精氨酸、胍和甲基胍的血清水平显著升高。在脑中，仅在癫痫发作期间肌酐和N-α-乙酰精氨酸显著增加。这些数据表明，在听源性癫痫发作期间血液中胍基化合物水平有明显变化，同时血清和脑中的肌酐也相应增加。
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