Thiriot C, Durand P, Jasseron M P, Kergonou J F, Ducousso R
Biochem Int. 1987 Jan;14(1):9-14.
In vitro lipid peroxidation initiated by NADPH/ADP/Fe3+ reveals an alteration of rat liver microsomal membrane at day D+4 after whole-body gamma irradiation (8Gy). This alteration is reversed by Trolox-C 100 microM plus GSH 2mM in association with the soluble supernatant from irradiated or control rats. The antioxidant capacity of the soluble supernatant is not inactivated by gamma irradiation. We conclude that the control of in vivo lipid peroxidation is membranous and cytosolic, and that the preservation of this activity is GSH and Vitamin E dependent.
由NADPH/ADP/Fe3+引发的体外脂质过氧化反应显示，在全身γ射线照射（8戈瑞）后第4天，大鼠肝微粒体膜发生了改变。100微摩尔的生育三烯酚-C加上2毫摩尔的谷胱甘肽与来自受照射或对照大鼠的可溶性上清液联合使用，可逆转这种改变。γ射线照射不会使可溶性上清液的抗氧化能力失活。我们得出结论，体内脂质过氧化的控制是膜性和胞质的，并且这种活性的维持依赖于谷胱甘肽和维生素E。
