Schaaf Cecilia R, Gonzalez Liara M
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States.
Front Vet Sci. 2022 May 20;9:878952. doi: 10.3389/fvets.2022.878952. eCollection 2022.
For both human and veterinary patients, non-infectious intestinal disease is a major cause of morbidity and mortality. To improve treatment of intestinal disease, large animal models are increasingly recognized as critical tools to translate the basic science discoveries made in rodent models into clinical application. Large animal intestinal models, particularly porcine, more closely resemble human anatomy, physiology, and disease pathogenesis; these features make them critical to the pre-clinical study of intestinal disease treatments. Previously, large animal model use has been somewhat precluded by the lack of genetically altered large animals to mechanistically investigate non-infectious intestinal diseases such as colorectal cancer, cystic fibrosis, and ischemia-reperfusion injury. However, recent advances and increased availability of gene editing technologies has led to both novel use of large animal models in clinically relevant intestinal disease research and improved testing of potential therapeutics for these diseases.
对于人类和兽医患者而言，非感染性肠道疾病是发病和死亡的主要原因。为了改善肠道疾病的治疗，大型动物模型越来越被视为将在啮齿动物模型中取得的基础科学发现转化为临床应用的关键工具。大型动物肠道模型，尤其是猪模型，更接近人类的解剖结构、生理机能和疾病发病机制；这些特性使它们对于肠道疾病治疗的临床前研究至关重要。以前，由于缺乏经过基因改造的大型动物来从机制上研究诸如结直肠癌、囊性纤维化和缺血再灌注损伤等非感染性肠道疾病，大型动物模型的使用在一定程度上受到了限制。然而，基因编辑技术的最新进展和可用性的提高，已导致大型动物模型在临床相关肠道疾病研究中的新应用，以及对这些疾病潜在疗法的更好测试。
