Nishida M, Murakawa T, Kamimura T, Okada N
Antimicrob Agents Chemother. 1978 Jul;14(1):6-12. doi: 10.1128/AAC.14.1.6.
The bactericidal activity of cefazolin, cephaloridine, and cephalothin in a simulated intramuscular study (500 mg) and a simulated intravenous drip infusion study (2 g/2 h) is reported. In both model systems, the bactericidal activity of cefazolin surpassed that of cephalothin, and there were certain differences between cefazolin and cephaloridine in the simulated intramuscular study when human serum was used as a medium. In a routine reference static system, the drug levels were constant at the simulated peak level of each cephalosporin by both routes. In this system the three cephalosporins were equal in activity. In a third experiment, the effect of drug concentrations and exposure time on bactericidal activity of the cephalosporins was studied. The bactericidal activity of cephaloridine was the strongest of the three drugs when exposure time was 2 h and drug concentration was less than four times the minimal inhibitory concentration. At concentrations above four times the minimum inhibitory concentration, all three cephalosporins were equal in activity when the exposure time was 2 h.
报道了头孢唑林、头孢噻啶和头孢噻吩在模拟肌内注射研究（500毫克）和模拟静脉滴注研究（2克/2小时）中的杀菌活性。在这两种模型系统中，头孢唑林的杀菌活性超过了头孢噻吩，并且在以人血清为介质的模拟肌内注射研究中，头孢唑林和头孢噻啶之间存在一定差异。在常规参考静态系统中，通过两种途径，药物水平在每种头孢菌素的模拟峰值水平保持恒定。在该系统中，三种头孢菌素的活性相当。在第三个实验中，研究了药物浓度和暴露时间对头孢菌素杀菌活性的影响。当暴露时间为2小时且药物浓度低于最低抑菌浓度的四倍时，头孢噻啶的杀菌活性在三种药物中最强。当浓度高于最低抑菌浓度的四倍时，暴露时间为2小时时，所有三种头孢菌素的活性相当。
