用于评估抗生素杀菌效果的新型体外动力学模型。
New in vitro kinetic model for evaluating bactericidal efficacy of antibiotics.
作者信息
Murakawa T, Sakamoto H, Hirose T, Nishida M
出版信息
Antimicrob Agents Chemother. 1980 Sep;18(3):377-81. doi: 10.1128/AAC.18.3.377.
Abstract
A new in vitro model was devised for evaluating the bactericidal activity of antibiotics under dynamic conditions. This model accurately reproduced the observed serum levels of antibiotics after intravenous dosing. The apparatus consists of two vessels which correspond to the central and peripheral compartments of a two-compartment open model. The volume of medium in each vessel and flow rates of media were determined from the pharmacokinetic parameters calculated from the observed serum levels selected for simulation. The bactericidal activity of cefazolin against strains of Escherichia coli and Klebsiella pneumoniae showing different minimal inhibitory concentrations was investigated with the apparatus simulating serum levels after intravenous injection, and the bactericidal activity was evaluated with respect to the relationship between the minimal inhibitory concentration and the serum levels.
摘要
设计了一种新的体外模型，用于评估动态条件下抗生素的杀菌活性。该模型准确再现了静脉给药后观察到的抗生素血清水平。该装置由两个容器组成，分别对应两室开放模型的中央室和外周室。每个容器中培养基的体积和培养基流速根据从为模拟选择的观察到的血清水平计算出的药代动力学参数来确定。使用模拟静脉注射后血清水平的装置研究了头孢唑林对表现出不同最低抑菌浓度的大肠杆菌和肺炎克雷伯菌菌株的杀菌活性，并根据最低抑菌浓度与血清水平之间的关系评估了杀菌活性。
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