O'Donnell B F, Squires N K, Martz M J, Chen J R, Phay A J
Biol Psychol. 1987 Feb;24(1):23-37. doi: 10.1016/0301-0511(87)90097-4.
Auditory brainstem responses (ABRs) and long latency exogenous and endogenous auditory evoked potentials (EPs) were investigated in 16 patients with Parkinson's disease and 11 control subjects. Parkinson's disease patients were impaired on mental status testing. While ABRs and the N1 component of the auditory EP were of normal latency in Parkinson patients, the endogenous components, N2 and P3, were prolonged. Prolongation of P3 latency in Parkinson's disease correlated with mental status decline, but not with severity of motoric disturbance. Thirteen PD patients also received neuropsychological evaluation. P3 latency was correlated with tests requiring learning or mental manipulation of information, but not with measures of verbal performance, immediate memory, or depression. P3 latency prolongation appears to have a selective relationship to intellectual changes in PD, and may be most sensitive to deficits requiring significant cognitive effort.
对16例帕金森病患者和11名对照受试者进行了听觉脑干反应（ABR）以及长潜伏期外源性和内源性听觉诱发电位（EP）的研究。帕金森病患者在精神状态测试中表现受损。虽然帕金森病患者的ABR和听觉EP的N1成分潜伏期正常，但内源性成分N2和P3延长。帕金森病中P3潜伏期延长与精神状态下降相关，但与运动障碍的严重程度无关。13例帕金森病患者还接受了神经心理学评估。P3潜伏期与需要学习或对信息进行心理操作的测试相关，但与言语表现、即时记忆或抑郁的测量无关。P3潜伏期延长似乎与帕金森病的智力变化存在选择性关系，并且可能对需要大量认知努力的缺陷最为敏感。
