阿尔茨海默病和遗忘型轻度认知障碍患者的动态磁敏感对比增强磁共振与 FDG-PET 脑研究比较。
Comparison of dynamic susceptibility contrast enhanced MR and FDG-PET brain studies in patients with Alzheimer's disease and amnestic mild cognitive impairment.
机构信息
Department of General and Interventional Radiology and Neuroradiology, Medical University Hospital, Borowska 213, 50-556, Wroclaw, Poland.
Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland.
出版信息
J Transl Med. 2022 Jun 7;20(1):259. doi: 10.1186/s12967-022-03464-x.
BACKGROUND
The aim of this study was to compare Dynamic Susceptibility Contrast Enhanced MRI (DSC-MRI) and PET with [18F]flurodeoxyglucose (FDG-PET) in the diagnosis of Alzheimer's Disease (AD) and amnestic Mild Cognitive Impairment (aMCI).
METHODS
Twenty-seven age-and sex-matched patients with AD, 39 with aMCI and 16 controls underwent brain DSC-MRI followed by FDG-PET. Values of relative Cerebral Blood Volume (rCBV) and rCBV z-scores from frontal, temporal, parietal and PCG cortices were correlated with the rate of glucose metabolism from PET. Sensitivity, specificity and accuracy of DSC-MRI and FDG-PET in the diagnosis of AD and aMCI were assessed and compared.
RESULTS
In AD, hypoperfusion was found within all the examined locations, while in aMCI in both parietal and temporal cortices and left PCG. FDG-PET showed the greatest hypometabolism in parietal, temporal and left PCG regions in both AD and aMCI. FDG-PET was more accurate in distinguishing aMCI from the controls than DSC-MRI. In the AD and combined group (AD + aMCI) there were numerous correlations between DSC-MRI and FDG-PET results.
CONCLUSIONS
In AD the patterns of hypoperfusion and glucose hypometabolism are similar, thus DSC-MRI may be a competitive method to FDG-PET. FDG-PET is a more accurate method in the diagnosis of aMCI.
背景
本研究旨在比较动态磁敏感对比增强磁共振成像（DSC-MRI）与正电子发射断层扫描（PET）联合氟脱氧葡萄糖（FDG-PET）在阿尔茨海默病（AD）和遗忘型轻度认知障碍（aMCI）中的诊断价值。
方法
27 例年龄和性别匹配的 AD 患者、39 例 aMCI 患者和 16 例对照组患者接受了脑 DSC-MRI 检查，随后进行了 FDG-PET 检查。从额、颞、顶和 PCG 皮质获得的相对脑血容量（rCBV）和 rCBV z 分数与 PET 葡萄糖代谢率相关。评估和比较了 DSC-MRI 和 FDG-PET 在 AD 和 aMCI 诊断中的敏感性、特异性和准确性。
结果
在 AD 中，在所有检查的部位都发现了低灌注，而在 aMCI 中，在顶叶和颞叶皮质以及左侧 PCG 也发现了低灌注。在 AD 和 aMCI 中，FDG-PET 在顶叶、颞叶和左侧 PCG 区域显示出最大的低代谢。与 DSC-MRI 相比，FDG-PET 在区分 aMCI 与对照组方面更准确。在 AD 和合并组（AD+aMCI）中，DSC-MRI 和 FDG-PET 结果之间存在大量相关性。
结论
在 AD 中，低灌注和葡萄糖低代谢的模式相似，因此 DSC-MRI 可能是 FDG-PET 的一种竞争方法。FDG-PET 是诊断 aMCI 的更准确方法。
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