半数致死剂量的区间估计。
Interval estimation of the median lethal dose.
作者信息
Williams D A
出版信息
Biometrics. 1986 Sep;42(3):641-5.
PMID:3567296
Abstract
Assuming a logistic dose-response curve, one can construct a confidence interval for the LD50 from the asymptotic likelihood ratio test. Reasons are given for preferring this likelihood ratio interval to the established interval calculated by applying Fieller's theorem to the maximum likelihood estimates.
摘要
假设为逻辑剂量反应曲线，可根据渐近似然比检验构建半数致死剂量（LD50）的置信区间。文中给出了倾向于使用此似然比区间而非通过将菲勒定理应用于最大似然估计值来计算的既定区间的理由。
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