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Exercise and Urtica dioica extract ameliorate hippocampal insulin signaling, oxidative stress, neuroinflammation, and cognitive function in STZ-induced diabetic rats.运动和荨麻提取物可改善 STZ 诱导的糖尿病大鼠海马胰岛素信号、氧化应激、神经炎症和认知功能。
Biomed Pharmacother. 2021 Jul;139:111577. doi: 10.1016/j.biopha.2021.111577. Epub 2021 Apr 8.
2
Whole Vegetable as a Functional Food Targeting Fat Accumulation and Insulin Resistance-a Preliminary Study in a Mouse Pre-Diabetic Model.全蔬菜作为一种功能性食品，针对脂肪积累和胰岛素抵抗 - 一种在小鼠糖尿病前期模型中的初步研究。
Nutrients. 2020 Apr 10;12(4):1059. doi: 10.3390/nu12041059.
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Anti-diabetic potential of plant alkaloids: Revisiting current findings and future perspectives.植物生物碱的抗糖尿病潜力：重新审视当前的发现和未来的展望。
Pharmacol Res. 2020 May;155:104723. doi: 10.1016/j.phrs.2020.104723. Epub 2020 Feb 24.
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Silymarin, Olibanum, and Nettle, A Mixed Herbal Formulation in the Treatment of Type II Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial.水飞蓟素、乳香和荨麻，一种用于治疗II型糖尿病的混合草药配方：一项随机、双盲、安慰剂对照临床试验
J Evid Based Complementary Altern Med. 2017 Oct;22(4):603-608. doi: 10.1177/2156587217696929. Epub 2017 Mar 21.
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Global aetiology and epidemiology of type 2 diabetes mellitus and its complications.2 型糖尿病及其并发症的全球病因学和流行病学。
Nat Rev Endocrinol. 2018 Feb;14(2):88-98. doi: 10.1038/nrendo.2017.151. Epub 2017 Dec 8.
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Effects of supplementation on blood lipids, hepatic enzymes and nitric oxide levels in type 2 diabetic patients: A double blind, randomized clinical trial.补充剂对2型糖尿病患者血脂、肝酶和一氧化氮水平的影响：一项双盲随机临床试验。
Avicenna J Phytomed. 2016 Nov-Dec;6(6):686-695.
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Mechanisms underlying the antihypertensive properties of Urtica dioica.荨麻降压特性的潜在机制。
J Transl Med. 2016 Sep 1;14(1):254. doi: 10.1186/s12967-016-1017-3.
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An extract of Urtica dioica L. mitigates obesity induced insulin resistance in mice skeletal muscle via protein phosphatase 2A (PP2A).荨麻提取物通过蛋白磷酸酶2A（PP2A）减轻小鼠骨骼肌中肥胖诱导的胰岛素抵抗。
Sci Rep. 2016 Feb 26;6:22222. doi: 10.1038/srep22222.

荨麻的抗糖尿病潜力：当前认知与未来方向。

Anti-diabetic potential of Urtica Dioica: current knowledge and future direction.

作者信息

Chehri Anita, Yarani Reza, Yousefi Zahra, Novin Bahador Tannaz, Shakouri Seyed Kazem, Ostadrahimi Alireza, Mobasseri Majid, Pociot Flemming, Araj-Khodaei Mostafa

机构信息

Student Research Committee, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Department of Persian Medicine, Faculty of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

J Diabetes Metab Disord. 2022 Jan 13;21(1):931-940. doi: 10.1007/s40200-021-00942-9. eCollection 2022 Jun.

DOI:10.1007/s40200-021-00942-9
PMID:35673511
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9167344/
Abstract

AIM

This review summarizes studies on the anti-diabetic effect of Urtica Dioica (UD) in Type-2-diabetes.

MATERIALS AND METHODS

We studied worldwide traditional medicines, old texts, and published literature for anti-diabetic effect of UD. Electronic databases comprising PubMed, Web of Science, Science Direct, Scopus and Google Scholar were searched to collect articles published between 1990 and 2021 years.

RESULTS

Our literature investigation suggests UD as a glucose lowering, blood lipid regulating, anti-inflammatory and anti-oxidation plant.

CONCLUSIONS

UD's anti-diabetic properties make it potential traditional therapeutics for lowering the clinical manifestations of T2DM through affecting hyperglycemia and therefore suggest it as a proper medication with no or limited side effects.

摘要

目的

本综述总结了荨麻对2型糖尿病的抗糖尿病作用的研究。

材料与方法

我们研究了世界各地的传统药物、古籍以及已发表的关于荨麻抗糖尿病作用的文献。检索了包括PubMed、科学网、Science Direct、Scopus和谷歌学术在内的电子数据库，以收集1990年至2021年间发表的文章。

结果

我们的文献研究表明，荨麻是一种具有降血糖、调节血脂、抗炎和抗氧化作用的植物。

结论

荨麻的抗糖尿病特性使其有可能成为通过影响高血糖来降低2型糖尿病临床表现的传统疗法，因此表明它是一种副作用少或无副作用的合适药物。