Khalili Nahid, Fereydoonzadeh Reza, Mohtashami Reza, Mehrzadi Saeed, Heydari Mojtaba, Huseini Hasan Fallah
1 Department of Internal Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.
2 Religion and Medicine Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
J Evid Based Complementary Altern Med. 2017 Oct;22(4):603-608. doi: 10.1177/2156587217696929. Epub 2017 Mar 21.
Silybum marianum (L) Gaertn (milk thistle) seeds, Urtica dioica L (nettle) leaves, and Boswellia serrata (olibanum gum) resin are used traditionally by Iranian diabetic patients. The aim of this study was to evaluate the antihyperglycemic effects of these herbs in an herbal formulation in patients with type II diabetes mellitus. Sixty patients diagnosed as type II diabetes mellitus with fasting blood glucose level from 150 to 180 mg/dL, glycosylated hemoglobin level from 7.5% to 8.5%, and on oral antihyperglycemic drugs, were allocated to receive the mix herbal formulation or placebo for 90 days in a double-blind randomized placebo-controlled clinical trial. The mean serum fasting blood glucose, glycosylated hemoglobin, and triglyceride in the herbal drug group were significantly less than placebo group's values after 3 months of the intervention. The study showed a potential antihyperglycemic and triglyceride lowering effect of the herbal formulation, while it did not have any significant cholesterol or blood pressure lowering effect.
水飞蓟（奶蓟）种子、荨麻叶和乳香树脂在伊朗糖尿病患者中传统上被使用。本研究的目的是评估这些草药的一种草药配方对II型糖尿病患者的降血糖作用。在一项双盲随机安慰剂对照临床试验中，60名被诊断为II型糖尿病、空腹血糖水平为150至180mg/dL、糖化血红蛋白水平为7.5%至8.5%且正在服用口服降糖药的患者，被分配接受混合草药配方或安慰剂，为期90天。干预3个月后，草药组的平均空腹血糖、糖化血红蛋白和甘油三酯显著低于安慰剂组的值。该研究表明该草药配方具有潜在的降血糖和降低甘油三酯的作用，而对胆固醇或血压没有显著的降低作用。
