饮酒与多发性硬化症的风险过高有关：一项荟萃分析观察性研究。
Alcohol consumption is associated with excessive risk of multiple sclerosis: a meta-analysis observational study.
机构信息
MD. Physician and Associate Professor, Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
PhD. Physician and Associate Professor, Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
出版信息
Sao Paulo Med J. 2022 Jul-Aug;140(4):518-524. doi: 10.1590/1516-3180.2021.0075.R1.14092021.
BACKGROUND
There have been inconsistent results regarding the association between alcohol intake and susceptibility to multiple sclerosis.
OBJECTIVE
To assess the potential role of alcohol intake regarding the risk of multiple sclerosis by using a meta-analytic approach.
DESIGN AND SETTING
Observational meta-analysis study conducted in a hospital in China.
METHODS
The electronic databases of PubMed, EMBASE and the Cochrane library were systematically searched for eligible studies from their inception up to January 2020. The summary odds ratio (OR) with 95% confidence interval (CI) was applied to assess the association between alcohol intake and multiple sclerosis, using a random-effects model.
RESULTS
One prospective cohort study and eight case-control studies involving a total of 211,396 subjects and 10,407 cases of multiple sclerosis were selected for the final meta-analysis. From the pooled data, no significant association between alcohol intake and multiple sclerosis risk was found (OR: 0.94; 95% CI: 0.73-1.22; P = 0.668), and this conclusion was judged to be robust. Subgroup analysis found that intake of beer was associated with an increased risk of multiple sclerosis (OR: 1.58; 95% CI: 1.12-2.23; P = 0.010).
CONCLUSION
This study found that beer intake could cause an excess risk of multiple sclerosis. Further large-scale prospective studies should be conducted to verify this conclusion.
背景
关于饮酒与多发性硬化症易感性之间的关系，结果一直不一致。
目的
通过荟萃分析方法评估饮酒与多发性硬化症风险之间的潜在关系。
设计和设置
在中国一家医院进行的观察性荟萃分析研究。
方法
系统检索了 PubMed、EMBASE 和 Cochrane 图书馆的电子数据库，以获取从成立到 2020 年 1 月的合格研究。使用随机效应模型，应用汇总优势比（OR）及其 95%置信区间（CI）来评估饮酒与多发性硬化症之间的关联。
结果
最终的荟萃分析纳入了一项前瞻性队列研究和八项病例对照研究，共涉及 211396 名受试者和 10407 例多发性硬化症病例。汇总数据显示，饮酒与多发性硬化症风险之间无显著关联（OR：0.94；95%CI：0.73-1.22；P=0.668），且这一结论被认为是稳健的。亚组分析发现，饮用啤酒与多发性硬化症风险增加相关（OR：1.58；95%CI：1.12-2.23；P=0.010）。
结论
本研究发现，饮用啤酒可能会导致多发性硬化症的风险增加。应进行更大规模的前瞻性研究来验证这一结论。
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