Bancewicz J, Mughal M, Marples M
Br J Surg. 1987 Mar;74(3):162-4. doi: 10.1002/bjs.1800740304.
The pressure and intra-abdominal length of the lower oesophageal sphincter (LOS) were measured by oesophageal manometry before and after floppy Nissen fundoplication (FNP) for intractable gastrooesophageal reflux. Control of reflux was assessed by 24 h pH recording and endoscopy. It was complete in 67 cases (84.8 per cent) in this non-consecutive series. In the group as a whole LOS pressure increased significantly after FNP, but the intra-abdominal length did not. LOS pressure decreased in 21 cases of whom 16 (76.2 per cent) still had perfect reflux control. Likewise, intra-abdominal length decreased in 41 cases of whom 36 (87.8 per cent) had good reflux control. There was no evidence of a compensatory increase in length to account for reflux control when LOS pressure decreased. When a length-pressure diagram was plotted for the postoperative measurements no clear separation of those with persistent reflux could be seen. These results suggest that the measured changes in LOS pressure and length following FNP are an artefact of surgery rather than the means by which the operation controls gastro-oesophageal reflux.
对于顽固性胃食管反流,在进行松弛性Nissen胃底折叠术(FNP)前后,通过食管测压法测量食管下括约肌(LOS)的压力和腹内长度。通过24小时pH记录和内镜检查评估反流的控制情况。在这个非连续系列中,67例(84.8%)的反流得到了完全控制。在整个组中,FNP术后LOS压力显著升高,但腹内长度未增加。21例LOS压力下降,其中16例(76.2%)仍有完美的反流控制。同样,41例腹内长度下降,其中36例(87.8%)有良好的反流控制。当LOS压力下降时,没有证据表明长度会有代偿性增加以解释反流的控制情况。当绘制术后测量的长度-压力图时,无法清晰区分仍有持续性反流的患者。这些结果表明,FNP术后LOS压力和长度的测量变化是手术造成的假象,而非该手术控制胃食管反流的方式。