Department of Intensive Care, Holbaek Hospital, Holbaek, Denmark.
Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Acta Anaesthesiol Scand. 2022 Sep;66(8):1024-1026. doi: 10.1111/aas.14099. Epub 2022 Jun 22.
Gastrointestinal motility is an important contributor to the effective uptake of water and nutrition. However, it is often impaired in acutely ill hospitalised patients. Amongst other indications, prokinetic agents are used to improve GI motility, but the body of evidence is not well described. Accordingly, we aim to systematically describe and explore the body of evidence on the use of prokinetic agents in hospitalised adults.
In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews statement, we plan to conduct a scoping review of studies assessing the use of prokinetic agents, for any indication, in hospitalised adults. We plan to assess study design, population, agents, indications and outcomes across included studies. When applicable, we plan to assess the certainty of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.
We plan to provide descriptive analyses of the included studies accompanied by tabulated results and characterise knowledge gaps.
The outlined scoping review will provide a summary of the body of evidence on the use, indications, effects and side effects of prokinetic agents in hospitalised adults.
胃肠道动力是有效吸收水分和营养的重要因素。然而，在急性住院的患者中，胃肠道动力常常受损。除其他适应证外，促动力药物也被用于改善胃肠道动力，但证据并不充分。因此，我们旨在系统地描述和探讨促动力药物在住院成人中的应用证据。
根据系统评价和荟萃分析扩展的首选报告项目声明，我们计划对评估促动力药物（任何适应证）在住院成人中的应用的研究进行范围综述。我们计划评估纳入研究的研究设计、人群、药物、适应证和结局。在适用的情况下，我们计划使用推荐评估、制定和评估（GRADE）方法评估证据的确定性。
我们计划对纳入的研究进行描述性分析，并以表格形式呈现结果，并描述知识空白。
该范围综述将总结促动力药物在住院成人中的应用、适应证、效果和副作用的证据。
