Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province & Institute of Advanced Technology and Nanomaterials, College of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, P. R. China.
Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan 430060, P. R. China.
ACS Appl Mater Interfaces. 2022 Jun 22;14(24):27733-27742. doi: 10.1021/acsami.2c07671. Epub 2022 Jun 8.
Multifunctional nanoparticles (NPs) with simultaneous multimodal therapeutic and imaging capabilities are very necessary for biomedical applications. We successfully prepared bowl-shaped gold@polydopamine yolk-shell NPs (bowl-shaped Au@PDA YNPs) by a novel and facile method. The unique bowl-like structure enables a drug loading rate of 92% (920 μg mg). The bowl-shaped Au@PDA YNPs are biocompatible, have good photothermal conversion and strong near-infrared (NIR) absorption, and can control drug release under pH/NIR dual response. Bowl-shaped Au@PDA YNPs can also be employed as contrast agents for computed tomography/photoacoustic imaging for dual-modal imaging-guided chemotherapy and photothermal therapy due to the presence of Au NPs.
多功能纳米粒子（NPs）具有同时进行多模式治疗和成像的能力，非常适用于生物医学应用。我们通过一种新颖且简便的方法成功制备了碗状金@聚多巴胺核壳纳米粒子（bowl-shaped Au@PDA YNPs）。独特的碗状结构使药物负载率达到 92%（920μgmg）。碗状 Au@PDA YNPs 具有生物相容性、良好的光热转换和强近红外（NIR）吸收能力，并能在 pH/NIR 双重响应下控制药物释放。由于 Au NPs 的存在，碗状 Au@PDA YNPs 还可用作计算机断层扫描/光声成像的造影剂，用于双模式成像引导的化学疗法和光热疗法。
