Zhu Ge, Li Zhihan, Zhang Yuning, Meng Xiandi, Guan Meng, Hu Zheng, Yang Yong-Guang, Liu Kun, Sun Tianmeng
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, Jilin, China.
APL Bioeng. 2023 Mar 23;7(1):016116. doi: 10.1063/5.0144481. eCollection 2023 Mar.
To improve the biosafety of the nanodelivery system, this study developed novel monodisperse spherical aluminum nanoparticles (Al NPs) and evaluated their cytotoxicity and distribution and biotoxicity . Compared with gold nanoparticles of the same size, Al NPs not only had low cytotoxicity but also did not cause accumulation in major organs after intravenous injections. No significant abnormalities were observed in the serum biochemical indices of mice injected with Al NPs. Additionally, no substantial changes occurred in the histopathology of major organs, and no apparent biological toxicity was measured after consecutive injections of Al NPs. These results indicate that Al NPs have a good biological safety and provide a new method for developing low-toxicity nanomedicine.
为提高纳米递送系统的生物安全性，本研究制备了新型单分散球形铝纳米颗粒（Al NPs），并对其细胞毒性、分布及生物毒性进行了评估。与相同尺寸的金纳米颗粒相比，Al NPs不仅细胞毒性低，而且静脉注射后不会在主要器官中蓄积。注射Al NPs的小鼠血清生化指标未观察到明显异常。此外，主要器官的组织病理学未发生实质性变化，连续注射Al NPs后未检测到明显的生物毒性。这些结果表明，Al NPs具有良好的生物安全性，为开发低毒纳米药物提供了一种新方法。
