Reddy Rebecca, Baijnath Sooraj, Moodley Roshila, Moodley Jagidesa, Naicker Thajasvarie, Govender Nalini
Department of Basic Medical Science, Faculty of Health Sciences, Durban University of Technology, Durban, South Africa.
Catalysis and Peptide Research Unit, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
J Ayurveda Integr Med. 2022 Apr-Jun;13(2):100562. doi: 10.1016/j.jaim.2022.100562. Epub 2022 Jun 5.
In resource-limited settings, such as South Africa, hypertensive disorders of pregnancy such as preeclampsia, is the most common direct cause of maternal deaths. Current management strategies of preeclampsia primarily involve the use of pharmaceutical drugs, which are frequently associated with undesirable side-effects. Moreover, these drugs are often not easily accessible due to financial and economic constraints. Consequently, many patients rely on traditional medicine obtained from medicinal plants to manage health-related conditions. Angiotensin-converting enzyme inhibitors are widely used drugs for the management of preeclampsia. This narrative review aims to highlight the use of indigenous medicinal plants from South Africa with Angiotensin-converting enzyme inhibitory activity whilst also evaluating their potential use in the treatment of hypertension in pregnancy. This information will influence traditional healers and sangomas in their patient management. Furthermore, the antihypertensive potential of these plants will be unraveled thus facilitating the development of new naturally occurring pharmaceutical products to reduce maternal and neonatal mortality and morbidity.
在资源有限的地区，如南非，妊娠期高血压疾病（如子痫前期）是孕产妇死亡的最常见直接原因。目前子痫前期的管理策略主要涉及使用药物，而这些药物常常伴有不良副作用。此外，由于经济限制，这些药物往往不易获得。因此，许多患者依靠从药用植物中获取的传统药物来管理与健康相关的病症。血管紧张素转换酶抑制剂是广泛用于管理子痫前期的药物。本叙述性综述旨在强调南非具有血管紧张素转换酶抑制活性的本土药用植物的用途，同时评估它们在治疗妊娠期高血压方面的潜在用途。这些信息将影响传统治疗师和占卜师对患者的管理。此外，这些植物的降压潜力将被揭示，从而促进开发新的天然药物产品，以降低孕产妇和新生儿的死亡率及发病率。
