Cukurova University, Faculty of Medicine, Department of Pediatrics, Division of Neonatology, 01330, Adana, Turkey.
Cukurova University, Faculty of Medicine, Department of Pediatrics, Division of Neonatology, 01330, Adana, Turkey.
Nutr Res. 2022 Aug;104:101-107. doi: 10.1016/j.nutres.2022.05.001. Epub 2022 May 17.
Vitamin B12, folate, and other micronutrients are essential for healthy growth. We hypothesized that there is a high prevalence of vitamin B12 deficiency in mothers and their newborns, and that blood serum vitamin B12 and folate levels may affect anthropometric measurements at birth. A total of 204 newborn babies and their 196 mothers were included. Blood samples of newborns and mothers were obtained for vitamin B12 (<200 pg/mL) and folate (<3 ng/mL) deficiencies. Additionally, iron and ferritin levels were measured. The mean gestational age and birth weight were 37.2 ± 2.6 (22.3-41) weeks and 3045 ± 770 (505-4525) g, respectively. All micronutrient levels in cord blood were higher than maternal levels (P = .001). A total of 96.3% of mothers and 64.5% of babies had vitamin B12 deficiency; 4% of mothers and none of the infants had folate deficiency. In total, 38.2% of mothers and 10.6% of infants had ferritin deficiency and 38.7% of mothers and 41.4% of newborns had iron deficiency. There was a negative correlation between cord vitamin B12 level and birth weight and head circumference (r = -0.21, P = .004 and r = -0.16, P = .036, respectively), whereas no correlation was found between maternal micronutrient status and anthropometric measurements of newborns. In conclusion, anthropometric measurements were unaffected by maternal levels, but vitamin B12 deficiency is very common in pregnant women and newborn babies. Mothers and their infants may benefit from early diagnosis and treatment. Awareness of vitamin B12 deficiency in pregnant women and newborns should be increased in Turkey.
维生素 B12、叶酸和其他微量营养素是健康生长所必需的。我们假设母亲及其新生儿中维生素 B12 缺乏症的患病率很高，并且血清维生素 B12 和叶酸水平可能会影响出生时的人体测量指标。共有 204 名新生儿及其 196 名母亲入组。采集新生儿和母亲的血液样本以检测维生素 B12（<200 pg/mL）和叶酸（<3 ng/mL）缺乏症。此外，还测量了铁和铁蛋白水平。平均胎龄和出生体重分别为 37.2 ± 2.6（22.3-41）周和 3045 ± 770（505-4525）g。脐带血中的所有微量营养素水平均高于母体水平（P =.001）。96.3%的母亲和 64.5%的婴儿存在维生素 B12 缺乏症；4%的母亲和无婴儿存在叶酸缺乏症。共有 38.2%的母亲和 10.6%的婴儿存在铁蛋白缺乏症，38.7%的母亲和 41.4%的新生儿存在铁缺乏症。脐带血维生素 B12 水平与出生体重和头围呈负相关（r = -0.21，P =.004 和 r = -0.16，P =.036），而母体微量营养素状况与新生儿的人体测量指标之间无相关性。结论：人体测量指标不受母体水平影响，但孕妇和新生儿中维生素 B12 缺乏症非常普遍。母亲及其婴儿可能受益于早期诊断和治疗。应提高土耳其人对孕妇和新生儿维生素 B12 缺乏症的认识。
