印度南部沿海营养不良母亲所生足月新生儿的母婴维生素 B12 水平与人体测量学的关系。
Association of maternal and cord vitamin B12 levels with anthropometry in term neonates born to malnourished mothers in coastal South India.
机构信息
Pediatrics, Kastrurba Medical College Mangalore Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Community Medicine, Kasturba Medical College Mangalore Manipal Academy Of Higher Education, Manipal, Karnataka, 576104, India.
出版信息
F1000Res. 2024 Jul 23;13:530. doi: 10.12688/f1000research.150696.2. eCollection 2024.
BACKGROUND
Malnourished pregnant women are at increased risk of micronutrient deficiency. We assessed the vitamin B12 status in both malnourished and normally nourished pregnant women and their neonates. Additionally, we studied the association between maternal B12 levels, cord B12 levels and neonatal anthropometry.
METHODS
This cross-sectional study enrolled 63 malnourished and 63 normally nourished mothers and neonates. Maternal and cord blood samples were collected at the time of delivery for estimation of vitamin B12 levels. Maternal and cord vitamin B12 levels were compared using the Mann-Whitney U test. Neonatal anthropometry was correlated with maternal and cord B12 levels using Spearman's correlation. Data were analyzed using SPSS version 25.
RESULTS
Mean maternal age was 26.58 yrs. The median cord B12 levels were lower than the maternal B12 levels. Maternal B12 levels showed a strong positive correlation with cord B12 levels (rho = 0.879; p < 0.001). Maternal (p < 0.001) and cord (p < 0.001) vitamin B12 levels were significantly lower in the malnourished group than in the normally nourished group. In malnourished group, 66.8% mothers and 95.2% neonates were Vitamin B12 deficient, whereas 1.5% mothers and 4.7% neonates were vitamin B12 deficient in normally nourished group. In the malnourished group, maternal B12 levels were positively correlated with birth weight (rho 0.363, p = 0.003) and length (rho 0.330, p =0.008), whereas cord B12 levels were positively correlated with birth weight in the normally nourished group. (rho 0.277 p= 0.028).
CONCLUSION
High rates of vitamin B12 deficiency were observed in malnourished mothers and neonates. There was a positive correlation between birth weight, length, and maternal vitamin B12 levels in malnourished mothers. These findings emphasize the need to address maternal malnutrition and vitamin B12 deficiency to improve neonatal health.
背景
营养不良的孕妇发生微量营养素缺乏的风险增加。我们评估了营养不良和营养良好的孕妇及其新生儿的维生素 B12 状况。此外，我们研究了母体 B12 水平、脐带 B12 水平与新生儿人体测量学指标之间的关系。
方法
本横断面研究纳入了 63 名营养不良和 63 名营养良好的母亲及其新生儿。在分娩时采集母体和脐带血样，以评估维生素 B12 水平。使用 Mann-Whitney U 检验比较母体和脐带血维生素 B12 水平。使用 Spearman 相关分析将新生儿人体测量学指标与母体和脐带 B12 水平相关联。使用 SPSS 版本 25 进行数据分析。
结果
母亲的平均年龄为 26.58 岁。脐带血 B12 水平中位数低于母体 B12 水平。母体 B12 水平与脐带 B12 水平呈强正相关（rho = 0.879；p < 0.001）。营养不良组的母体（p < 0.001）和脐带（p < 0.001）维生素 B12 水平明显低于营养良好组。在营养不良组中，66.8%的母亲和 95.2%的新生儿存在维生素 B12 缺乏，而营养良好组中分别为 1.5%的母亲和 4.7%的新生儿存在维生素 B12 缺乏。在营养不良组中，母体 B12 水平与出生体重呈正相关（rho 0.363，p = 0.003）和长度（rho 0.330，p =0.008），而在营养良好组中，脐带 B12 水平与出生体重呈正相关。（rho 0.277 p= 0.028）。
结论
营养不良的母亲及其新生儿存在较高的维生素 B12 缺乏率。营养不良母亲的出生体重、长度与母体维生素 B12 水平呈正相关。这些发现强调需要解决母婴营养不良和维生素 B12 缺乏问题，以改善新生儿健康。
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