Balcı Yasemin Işık, Ergin Ahmet, Karabulut Aysun, Polat Aziz, Doğan Mustafa, Küçüktaşcı Kazım
Department of Pediatric Hematology, Medical Faculty, Pamukkale University , Denizli , Turkey.
Pediatr Hematol Oncol. 2014 Feb;31(1):62-7. doi: 10.3109/08880018.2013.829894. Epub 2013 Oct 2.
Low vitamin B12 and folate levels in expectant mothers may lead to low stores in babies. The aim of this study was to determine the frequencies of vitamin B12 and folate deficiencies in pregnant women and neonates, and to assess the effect of maternal vitamin status on babies' vitamin levels in the Aegean region of Turkey, where the Mediterranean diet (mainly fresh fruits and vegetables) is adopted. We studied 72 pregnant women and their singleton-term babies. Venous blood samples of expectant mothers were collected 1 h before delivery and cord blood of babies were obtained at birth. The mean vitamin B12 in maternal and cord blood serum was 163.1 ± 72.0 pg/mL and 146.2 ± 102.5 pg/mL, and the mean folate, 9.8 ± 4.8 ng/mL and 15.8 ± 3.8 ng/mL, respectively. There were statistically significant correlation between maternal and cord blood serum vitamin B12 (r = 0.61, P = .04) and folate levels (r = 0.65, P < .001). 70.8% of the mothers and 83.9% of the babies were vitamin B12 deficient (<200 pg/mL). Neither group showed folate deficiency. The mean level of vitamin B12 in mothers significantly varied by the type of diet (241.6 (72.1) pg/mL versus 155.9 (68.2) pg/mL; P = .012). Vitamin B12 deficiency in pregnant women and neonates may be a public health problem in our community. The Mediterranean diet in these vulnerable groups may be an aggravating factor for vitamin B12 deficiency. Prenatal screening of all expectant mothers, prenatal supplementation of vitamin B12, and an increase in animal-source food intake may improve expectant mother's vitamin B12 level.
准妈妈体内维生素B12和叶酸水平偏低可能导致婴儿体内储备不足。本研究的目的是确定土耳其爱琴海地区孕妇和新生儿维生素B12和叶酸缺乏的发生率，并评估母亲维生素状态对婴儿维生素水平的影响，该地区采用地中海饮食（主要是新鲜水果和蔬菜）。我们研究了72名孕妇及其单胎足月婴儿。在分娩前1小时采集准妈妈的静脉血样本，并在婴儿出生时采集脐带血。母亲和脐带血血清中维生素B12的平均水平分别为163.1±72.0 pg/mL和146.2±102.5 pg/mL，叶酸的平均水平分别为9.8±4.8 ng/mL和15.8±3.8 ng/mL。母亲和脐带血血清维生素B12水平（r = 0.61，P = 0.04）及叶酸水平（r = 0.65，P < 0.001）之间存在统计学显著相关性。70.8%的母亲和83.9%的婴儿维生素B12缺乏（<200 pg/mL）。两组均未显示叶酸缺乏。母亲体内维生素B12的平均水平因饮食类型而有显著差异（241.6（72.1）pg/mL对155.9（68.2）pg/mL；P = 0.012）。孕妇和新生儿的维生素B12缺乏可能是我们社区的一个公共卫生问题。这些弱势群体的地中海饮食可能是维生素B12缺乏的一个加重因素。对所有准妈妈进行产前筛查、产前补充维生素B12以及增加动物源性食物的摄入量可能会提高准妈妈的维生素B12水平。
