Mok D, Mogenson G J
Brain Res. 1987 Mar 31;407(2):332-40. doi: 10.1016/0006-8993(87)91112-7.
Extracellular single-unit activity was recorded from 109 neurons in the diencephalon of urethane-anesthetized rats. Injections of angiotensin II (ANG II) into the subfornical organ (SFO) increased the activity of 15 zona incerta (ZI) neurons and decreased the activity of 9. Injections of ANG II into the SFO increased the activity of 8 lateral hypothalamic neurons and decreased the activity of 7. Of the units which responded to the injection of ANG II into the SFO, 9 neurons in the ZI and 5 in the lateral hypothalamus (LH) also responded to injections of hyperosmotic saline into the medial preoptic area. The SFO and preoptic area are possible sites of receptors for ANG II-mediated and osmotic thirst, respectively, and the present results suggest that signals important for the initiation of these thirst mechanisms converge on neurons in the ZI and LH. These findings are discussed in relation to other neural structures that have been implicated in the regulation of water intake.
在氨基甲酸乙酯麻醉的大鼠间脑中，从109个神经元记录了细胞外单单位活动。向穹窿下器官（SFO）注射血管紧张素II（ANG II）可增加15个未定带（ZI）神经元的活动，并降低9个神经元的活动。向SFO注射ANG II可增加8个下丘脑外侧神经元的活动，并降低7个神经元的活动。在对向SFO注射ANG II有反应的单位中，ZI中的9个神经元和下丘脑外侧（LH）中的5个神经元对向视前内侧区注射高渗盐水也有反应。SFO和视前区分别可能是ANG II介导的口渴和渗透性口渴的受体部位，目前的结果表明，对启动这些口渴机制很重要的信号汇聚在ZI和LH中的神经元上。结合其他与水摄入调节有关的神经结构对这些发现进行了讨论。
