石栗种子对肥胖Wistar大鼠的脂肪酸组成及体内生化效应
Fatty acids composition and in vivo biochemical effects of Aleurites moluccana seed (Candlenut) in obese wistar rats.
作者信息
de Britto Rosa Matheus Camargos, Ribeiro Paula Reis, de Oliveira Silva Viviam, Selvati-Rezende Danubia Aparecida de Carvalho, da Silva Tácio Peres, Souza Fernanda Rezende, Cardoso Maria das Graças, Seixas Josilene Nascimento, Andrade Eric Francelino, Pardi Vanessa, Murata Ramiro Mendonça, Pereira Luciano José
机构信息
Veterinary Medicine Department, Universidade Federal de Lavras, Mail Box 3037, Lavras, Minas Gerais, Brazil.
Department of Health Sciences, Universidade Federal de Lavras (UFLA), Mailbox 3037, Lavras, Minas Gerais, 37200-900, Brazil.
出版信息
Diabetol Metab Syndr. 2022 Jun 8;14(1):80. doi: 10.1186/s13098-022-00847-4.
BACKGROUND
Candlenut (CN) has been used indiscriminately for weight loss. In vivo effects of CN in different doses are scarce.
OBJECTIVE
To evaluate the effects of CN ingestion in obese rats.
DESIGN
Thirty animals (obese and non-obese) received one of three different types of treatments: placebo, CN ingestion in a popular therapeutic regimen (8 days with oral administration of 0.2 mg/kg followed by 20 days with doses of 0.4 mg/kg), and ingestion of a doubled popular dose-called 2CN. Treatment was maintained for 28 days.
RESULTS
The fatty acid profile of CN indicated mainly linolelaidic and palmitoleic acids. Rats receiving CN and 2CN showed reduced plasmatic levels of glucose and lipoproteins (p < 0.05). A dose-dependent carcass fat reduction was observed (p < 0.05). Blood levels of aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) reduced with CN and increased with 2CN doses (p < 0.05). Alanine aminotransferase (ALT) and the atherogenic index remained similar among all treatments (p > 0.05). Hepatic vacuolation decreased with CN, but the 2CN dose produced mononuclear leucocyte infiltrate.
CONCLUSIONS
Although CN presented beneficial effects on the metabolism of rats, it also caused increased risk of liver damage.
背景
桐油树坚果（CN）已被随意用于减肥。关于不同剂量CN的体内效应的研究较少。
目的
评估摄入CN对肥胖大鼠的影响。
设计
30只动物（肥胖和非肥胖）接受三种不同治疗之一：安慰剂、按照常用治疗方案摄入CN（口服0.2mg/kg，持续8天，随后20天服用0.4mg/kg剂量）以及摄入双倍常用剂量（称为2CN）。治疗持续28天。
结果
CN的脂肪酸谱主要显示为反式亚油酸和棕榈油酸。接受CN和2CN的大鼠血浆葡萄糖和脂蛋白水平降低（p<0.05）。观察到剂量依赖性的体脂减少（p<0.05）。随着CN剂量增加，天冬氨酸转氨酶（AST）和γ-谷氨酰转移酶（GGT）的血液水平降低，而随着2CN剂量增加则升高（p<0.05）。在所有治疗组中，丙氨酸转氨酶（ALT）和动脉粥样硬化指数保持相似（p>0.05）。CN使肝空泡化减少，但2CN剂量导致单核白细胞浸润。
结论
虽然CN对大鼠代谢有有益作用，但也增加了肝损伤风险。
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